Regulation of reproduction via tight control of gonadotropin hormone levels.
Regulation of reproduction via tight control of gonadotropin hormone levels.
复制标题
DOI：
10.1016/j.mce.2017.03.022
复制
发表时间：
2018-03-05
影响因子：
4.1
通讯作者：
Coss D
中科院分区：
文献类型：
--
作者：
Coss D
哺乳动物的生殖由下丘脑-垂体-性腺轴控制。来自下丘脑的GnRH调节促性腺激素、LH和FSH的合成和分泌，然后控制类固醇生成和配子生成。在女性中，血清LH和FSH水平在整个月经或发情周期中表现出与GnRH脉冲频率相关的节律性变化。缺乏促性腺激素会导致不孕或闭经。由于水平略超出正常范围而导致的严格控制比率的功能障碍发生在大量女性中，并与多囊卵巢和卵巢早衰相关。由于这些疾病的病因在很大程度上是未知的，在细胞和小鼠模型的研究可能会提供新的候选人在人群中的调查。因此，了解GnRH调节促性腺激素水平的机制将有助于深入了解生殖系统的生理学和病理生理学。本文综述了GnRH调节促性腺激素合成的最新进展。
Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH, which then control steroidogenesis and gametogenesis. In females, serum LH and FSH levels exhibit rhythmic changes throughout the menstrual or estrous cycle that are correlated with pulse frequency of GnRH. Lack of gonadotropins leads to infertility or amenorrhea. Dysfunctions in the tightly controlled ratio due to levels slightly outside the normal range occur in a larger number of women and are correlated with polycystic ovaries and premature ovarian failure. Since the etiology of these disorders is largely unknown, studies in cell and mouse models may provide novel candidates for investigations in human population. Hence, understanding the mechanisms whereby GnRH regulates gonadotropin hormone levels will provide insight into the physiology and pathophysiology of the reproductive system. This review discusses recent advances in our understanding of GnRH regulation of gonadotropin synthesis.
登录
查看更多内容
影响因子：
56.9
作者：
BELCHETZ, PE;PLANT, TM;KNOBIL, E
通讯作者：
KNOBIL, E
影响因子：
4.8
作者：
Chapman, SC;Woodruff, TK
通讯作者：
Woodruff, TK
影响因子：
4.8
作者：
Bonfil, D;Chuderland, D;Naor, Z
通讯作者：
Naor, Z
影响因子：
4.8
作者：
ATTARDI, B;FITZGERALD, T
通讯作者：
FITZGERALD, T
影响因子：
3.6
作者：
Burger LL;Haisenleder DJ;Aylor KW;Marshall JC
通讯作者：
Marshall JC