RCC1 Expression as a Prognostic Marker in Colorectal Liver Oligometastases.
RCC1 Expression as a Prognostic Marker in Colorectal Liver Oligometastases.
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RCC1 表达作为结直肠肝寡转移的预后标志物
DOI：
10.3389/pore.2021.1610077
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Pan Z
中科院分区：
文献类型：
--
作者：
Deng Y;Yu L;Zhao Y;Peng J;Xu Y;Qin J;Xiao B;Liu S;Li M;Fang Y;Pan Z
简介：染色质凝聚调节因子1（Regulator of chromatin condensation 1，RCC1）是Ran GTdR的主要鸟嘌呤核苷酸交换因子，在多种生物学过程中发挥重要作用。以往的研究发现RCC1可能在肿瘤的发生发展中发挥作用，但RCC1与结直肠肝寡转移酶（CLO）的关系尚不清楚。 研究方法：对129对匹配的人类CLO样本（包括原发肿瘤及其肝转移标本）进行免疫组化，以确定RCC1的位置和表达水平。RCC1和生存以及基因表达谱之间的关联进行了探讨。 结果如下：在这项研究中，我们首先观察到，与正常组织相比，RCC1在CLO肿瘤组织中轻度增加，并且定位主要是核。此外，我们的研究发现，肝寡转移中RCC1的高表达是不利的无复发生存期和总生存期的独立预后标志物（p = 0.036和p = 0.016）。基因表达谱分析表明RCC1参与了包括“Myc靶”、“E2F靶”和“DNA修复”途径在内的多种途径。 结论：我们的数据表明，RCC1主要在细胞核中表达，并且在RCC1表达水平与CLO患者的生存率之间发现了强而显著的关联。这些结果表明，RCC1可能在CLO的发展中发挥作用。
Introduction: Regulator of chromatin condensation 1 (RCC1) is a major guanine-nucleotide exchange factor for Ran GTPase, and it plays key roles in various biological processes. Previous studies have found that RCC1 may play a role in the development of tumors, but little is known about the relationship between RCC1 and colorectal liver oligometastases (CLOs). Methods: One hundred and twenty-nine pairs of matched human CLO samples, including both primary tumor and its liver metastasis specimens, were subjected to immunohistochemistry to determine the location and expression levels of RCC1. Associations between RCC1 and survival as well as gene expression profiling were explored. Results: In this study, we first observed that RCC1 was mildly increased in CLO tumor tissues compared with normal tissues, and the localization was primarily nuclear. In addition, our study found that high RCC1 expression in liver oligometastases was an independent prognostic marker for unfavorable recurrence-free survival and overall survival (p = 0.036 and p = 0.016). Gene expression profiles generated from microarray analysis showed that RCC1 was involved in pathways including “Myc targets,” “E2F targets” and “DNA repair” pathways. Conclusion: Our data indicated that RCC1 was expressed mainly in the nucleus, and strong and significant associations were found between RCC1 expression levels and the survival of CLO patients. These findings indicated that RCC1 may play a role in CLO development.
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影响因子：
7
作者：
Hsu, Chiung-Hung;Hsu, Chia-Wei;Yu, Chia-Jung
通讯作者：
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影响因子：
16.2
作者：
Feng, Rui-Mei;Zong, Yi-Nan;Xu, Rui-Hua
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Xu, Rui-Hua
影响因子：
3.8
作者：
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通讯作者：
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影响因子：
64.5
作者：
NISHIMOTO, T;EILEN, E;BASILICO, C
通讯作者：
BASILICO, C
DOI：
10.3324/haematol.12999
发表时间：
2008-08-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Tracey, Lorraine;Aggarwal, Mohit;Piris, Miguel A.
通讯作者：
Piris, Miguel A.