The pain imaging revolution: advancing pain into the 21st century.
The pain imaging revolution: advancing pain into the 21st century.
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DOI：
10.1177/1073858409349902
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Becerra L
中科院分区：
文献类型：
--
作者：
Borsook D;Sava S;Becerra L
在过去的几十年里，脑成像技术的巨大进步已经决定了我们对慢性疼痛的理解的转变，并为开发更好的诊断和更好的药物治疗打开了新的机会。神经影像学帮助形成了慢性疼痛的概念，从一种主要影响体感系统的疾病，到一种除了退行性过程外，还影响大脑的情绪、认知和调节区域的疾病。所有这些都有助于疼痛症状和共病特征的发展和维持，包括焦虑、抑郁和认知过程的改变。在本文中，我们回顾了目前对慢性疼痛的大脑变化的理解以及各种脑成像技术的应用所取得的进展。我们还讨论了脑成像在发展“疼痛表型”方面的可能应用，这可能有助于慢性疼痛的诊断和治疗选择。
The great advances in brain imaging techniques over the last few decades have determined a shift in our understanding of chronic pain conditions and opened the door for new opportunities to develop better diagnoses and perhaps better drug treatments. Neuroimaging has helped shape the concept of chronic pain from a disease affecting mainly the somatosensory system, to a condition in which emotional, cognitive and modulatory areas of the brain are affected, in addition to degenerative processes. All these contribute to the development and maintenance of pain symptoms and co-morbid features including alterations in anxiety, depression and cognitive processes. In this paper we review the current understanding of the brain changes in chronic pain and the developments made possible by the use of various brain imaging techniques. We also discuss the possible applications of brain imaging to developing a “pain phenotype” that could aid in diagnostic and treatment choices of chronic pain conditions.
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