Sequential organ failure assessment score can predict mortality in patients with paraquat intoxication.
Sequential organ failure assessment score can predict mortality in patients with paraquat intoxication.
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DOI：
10.1371/journal.pone.0051743
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Yen TH
中科院分区：
文献类型：
--
作者：
Weng CH;Hu CC;Lin JL;Lin-Tan DT;Huang WH;Hsu CW;Yen TH
百草枯中毒的特点是多器官衰竭和肺纤维化伴呼吸衰竭，死亡率和发病率高。本研究的目的是确定百草枯中毒病例中死亡率的预测因素。此外，我们试图确定这些参数之间的关联。在2000年1月至2010年12月期间，共有187名患者接受了故意摄入百草枯的治疗。记录人口统计学、临床和实验室数据。收集序贯器官衰竭评估（SOFA）和急性肾损伤网络（AKIN）评分，并分析死亡率预测因子。总体住院死亡率为54%（101/187）。使用多变量logistic回归模型，发现年龄、住院时间、血液百草枯水平、入院时估计肾小球滤过率（eGFR第一天）和SOFA48-h评分是死亡率的显著预测因子，而不是AKIN48-h评分。在预测住院死亡率方面，SOFA48-h评分在受试者工作特征曲线（AUROC）下显示出较好的面积（0.795±0.033，P<0.001）。SOFA48-h评分<3和≥3的患者累积生存率差异有统计学意义（P<0.001）。采用血中百草枯水平进一步建立了改进的SOFA （mSOFA）评分，该评分的AUROC（0.848±0.029，P<0.001）也优于原SOFA评分。最后，mSOFA评分<4和≥4的患者的累积生存率也有显著差异（P<0.001）。分析数据表明，基于器官功能程度或器官衰竭率的SOFA和mSOFA评分有助于预测故意百草枯中毒后的死亡率。
Paraquat poisoning is characterized by multi-organ failure and pulmonary fibrosis with respiratory failure, resulting in high mortality and morbidity. The objective of this study was to identify predictors of mortality in cases of paraquat poisoning. Furthermore, we sought to determine the association between these parameters. A total of 187 patients were referred for management of intentional paraquat ingestion between January 2000 and December 2010. Demographic, clinical, and laboratory data were recorded. Sequential organ failure assessment (SOFA) and acute kidney injury network (AKIN) scores were collected, and predictors of mortality were analyzed. Overall hospital mortality for the entire population was 54% (101/187). Using a multivariate logistic regression model, it was found that age, time to hospitalization, blood paraquat level, estimated glomerular filtration rate at admission (eGFR first day), and the SOFA48-h score, but not the AKIN48-h score, were significant predictors of mortality. For predicting the in-hospital mortality, SOFA48-h scores displayed a good area under the receiver operating characteristic curve (AUROC) (0.795±0.033, P<0.001). The cumulative survival rate differed significantly between patients with SOFA48-h scores <3 and those ≥3 (P<0.001). A modified SOFA (mSOFA) score was further developed by using the blood paraquat level, and this new score also demonstrated a better AUROC (0.848±0.029, P<0.001) than the original SOFA score. Finally, the cumulative survival rate also differed significantly between patients with mSOFA scores <4 and ≥4 (P<0.001). The analytical data demonstrate that SOFA and mSOFA scores, which are based on the extent of organ function or rate of organ failure, help to predict mortality after intentional paraquat poisoning.
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影响因子：
3.3
作者：
Min, Young-Gi;Ahn, Jung Hwan;Chan, Chi Keung
通讯作者：
Chan, Chi Keung
DOI：
10.1081/clt-120025356
发表时间：
2003-01-01
期刊：
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY
影响因子：
--
作者：
Lin, NC;Lin, JL;Yu, CC
通讯作者：
Yu, CC
影响因子：
7.6
作者：
Craig, D. G. N.;Reid, T. W. D. J.;Simpson, K. J.
通讯作者：
Simpson, K. J.
影响因子：
120.7
作者：
LEGALL, JR;LEMESHOW, S;SAULNIER, F
通讯作者：
SAULNIER, F
影响因子：
4.6
作者：
Cholongitas, Evangelos;Theocharidou, Eleni;Burroughs, Andrew K.
通讯作者：
Burroughs, Andrew K.