Environmental exposures to pesticides, phthalates, phenols and trace elements are associated with neurodevelopment in the CHARGE study.
Environmental exposures to pesticides, phthalates, phenols and trace elements are associated with neurodevelopment in the CHARGE study.
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在电荷研究中，环境暴露于农药，邻苯二甲酸盐，苯酚和微量元素与神经发育有关。
DOI：
10.1016/j.envint.2021.107075
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发表时间：
2022-03
影响因子：
11.8
通讯作者：
Hertz-Picciotto, Irva
中科院分区：
文献类型：
--
作者：
Bennett, Deborah H.;Busgang, Stefanie A.;Kannan, Kurunthachalam;Parsons, Patrick J.;Takazawa, Mari;Palmer, Christopher D.;Schmidt, Rebecca J.;Doucette, John T.;Schweitzer, Julie B.;Gennings, Chris;Hertz-Picciotto, Irva
确定与正常发育儿童（TD）相比，在幼儿期测量的环境酚类、邻苯二甲酸盐、农药和/或微量元素的较高暴露是否与诊断为自闭症谱系障碍（ASD）、发育迟缓（DD）或其他早期担忧（OEC）的几率增加相关。这项研究包括627名年龄在2-5岁之间的儿童，他们参加了遗传学和环境（CHARGE）研究的儿童自闭症风险。在同一研究访视时采集尿液样本，进行诊断评估以确认招募过程中指示的诊断。以诊断为结果，对每种化学物质进行了调整的多项式回归模型。此外，使用两种方法分析混合物：重复holdout多项式加权分位数和（WQS）回归每个化学类别;和总尿混合物的影响进行了评估与重复holdout随机子集WQS。与TD相比，许多尿液化学物质与ASD，DD或OEC的几率增加有关;然而，在错误发现率调整后，大多数化学物质并不显著。重复坚持WQS指数提供的证据，为协会的苯酚/对羟基苯甲酸酯的混合物的影响和微量元素的混合物的影响DD独立。在调整混杂因素和其他暴露的分析中，结果表明农药混合物效应与ASD风险增加有关。结果还表明，总尿混合物与ASD和DD的几率分别更大。与TD相比，ASD、DD和OEC的尿生物标志物浓度更高，比较单一化学分析和混合物分析的结果一致。鉴于用于化学分析的生物标本通常是在诊断后数月收集的，因此任何因果关系的方向都是未知的。因此，研究结果可能反映了由于行为、代谢或毒代动力学的差异，非典型发育儿童的暴露量高于TD儿童。
To determine if higher exposures measured in early childhood to environmental phenols, phthalates, pesticides, and/or trace elements, are associated with increased odds of having a diagnosis of Autism Spectrum Disorder (ASD), Developmental Delay (DD), or Other Early Concerns (OEC) compared to typically developing children (TD). This study included 627 children between the ages of 2–5 who participated in the Childhood Autism Risks from Genetics and Environment (CHARGE) study. Urine samples were collected at the same study visit where diagnostic assessments to confirm diagnosis indicated during the recruitment process were performed. Adjusted multinomial regression models of each chemical with diagnosis as the outcome were conducted. Additionally, two methods were used to analyze mixtures: repeated holdout multinomial weighted quantile sum (WQS) regression for each chemical class; and a total urinary mixture effect was assessed with repeated holdout random subset WQS. Many urinary chemicals were associated with increased odds of ASD, DD or OEC compared to TD; however, most did not remain significant after false discovery rate adjustment. Repeated holdout WQS indices provided evidence for associations of both a phenol/paraben mixture effect and a trace element mixture effect on DD independently. In analyses adjusted for confounders and other exposures, results suggested an association of a pesticide mixture effect with increased risk for ASD. Results also suggested associations of a total urinary mixture with greater odds of both ASD and DD separately.. Higher concentrations of urinary biomarkers were associated with ASD, DD, and OEC compared to TD, with consistency of the results comparing single chemical analyses and mixture analyses. Given that the biospecimens used for chemical analysis were generally collected many months after diagnoses were made, the direction of any causal association is unknown. Hence findings may reflect higher exposures among children with non-typical development than TD children due to differences in behaviors, metabolism, or toxicokinetics.
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影响因子：
10.4
作者：
通讯作者：
--
产前空气污染物暴露和孕产妇叶酸对自闭症谱系障碍风险的关节作用。
DOI：
10.1002/aur.1885
发表时间：
2018-01
期刊：
Autism research : official journal of the International Society for Autism Research
影响因子：
--
作者：
Goodrich AJ;Volk HE;Tancredi DJ;McConnell R;Lurmann FW;Hansen RL;Schmidt RJ
通讯作者：
Schmidt RJ
影响因子：
10.4
作者：
Barbosa F Jr;Tanus-Santos JE;Gerlach RF;Parsons PJ
通讯作者：
Parsons PJ
影响因子：
11.8
作者：
Li, Adela Jing;Martinez-Moral, Maria-Pilar;Kannan, Kurunthachalam
通讯作者：
Kannan, Kurunthachalam
DOI：
10.1080/03610918.2019.1577971
发表时间：
2019-08-24
影响因子：
0.9
作者：
Curtin, Paul;Kellogg, Joshua;Gennings, Chris
通讯作者：
Gennings, Chris