Eukaryotic 5S rRNA biogenesis.

Eukaryotic 5S rRNA biogenesis.
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DOI:
10.1002/wrna.74
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发表时间:
2011-07
影响因子:
7.3
通讯作者:
Williams, Noreen
Williams, Noreen
中科院分区:
生物学2区
文献类型:
--
作者:
Ciganda, Martin;Williams, Noreen

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核糖体是一种含有蛋白质和RNA的大型络合物,必须以精确的方式组装,以允许在蛋白质合成的关键作用中正确发挥作用。 5S rRNA是核糖体的RNA成分中最小的,尽管已经对其进行了数十年的研究,但我们仍然对其在复杂的核糖体机中的功能没有清晰的了解。它是唯一结合核糖体蛋白在核糖体之前结合核糖体蛋白的物种。它进入核仁需要这种相互作用。在这里,我们概述了有关5S rRNA的结构和功能以及其与特定蛋白质的关联如何影响其本地化和功能的一些关键发现。
The ribosome is a large complex containing both protein and RNA which must be assembled in a precise manner to allow proper functioning in the critical role of protein synthesis. 5S rRNA is the smallest of the RNA components of the ribosome, and although it has been studied for decades, we still do not have a clear understanding of its function within the complex ribosome machine. It is the only RNA species that binds ribosomal proteins prior to its assembly into the ribosome. Its transport into the nucleolus requires this interaction. Here we present an overview of some of the key findings concerning the structure and function of 5S rRNA and how its association with specific proteins impacts its localization and function.
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