From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?

From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?
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DOI:
10.1016/j.trsl.2021.09.001
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发表时间:
2022-03
期刊:
Translational research : the journal of laboratory and clinical medicine
影响因子:
--
通讯作者:
Schwartz DA
Schwartz DA
中科院分区:
其他
文献类型:
--
作者:
Michalski JE;Kurche JS;Schwartz DA

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自2019年底首次报道以来,冠状病毒病19 (COVID-19)大流行已经改变了医学界和科学界,但我们才刚刚开始了解与这种疾病相关的慢性健康负担。尽管COVID-19是一种多系统疾病,但肺部是感染和损伤的主要来源,可导致肺炎,严重者可导致急性呼吸窘迫综合征(ARDS)。鉴于肺纤维化是ARDS的公认后遗症,许多人质疑COVID-19幸存者是否会面临长期的肺部后果。本综述旨在将我们对纤维增殖性ARDS的病理生理机制的理解与我们目前对COVID-19疾病肺部后果的了解结合起来。
While the coronavirus disease 19 (COVID-19) pandemic has transformed the medical and scientific communites since it was first reported in late 2019, we are only beginning to understand the chronic health burdens associated with this disease. Although COVID-19 is a multi-systemic disease, the lungs are the primary source of infection and injury, resulting in pneumonia and, in severe cases, acute respiratory distress syndrome (ARDS). Given that pulmonary fibrosis is a well-recognized sequela of ARDS, many have questioned whether COVID-19 survivors will face long-term pulmonary consequences. This review is aimed at integrating our understanding of the pathophysiologic mechanisms underlying fibroproliferative ARDS with our current knowledge of the pulmonary consequences of COVID-19 disease.
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