The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance.
The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance.
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DOI：
10.1183/09031936.00196412
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
Downey GP
中科院分区：
文献类型：
--
作者：
Burnham EL;Janssen WJ;Riches DW;Moss M;Downey GP
急性呼吸窘迫综合征(ARDS)仍然是一个主要的医疗问题，每年在美国影响19万人，死亡率为27%-45%，这取决于疾病的严重程度和合并症。尽管在临床护理方面取得了进展，特别是机械通气的肺保护策略，但大多数幸存者在急性疾病后多年都经历了与健康相关的生活质量受损。虽然大多数患者在急性疾病中幸存下来，但部分ARDS幸存者出现了纤维增生性反应，其特征是成纤维细胞在肺内积聚和沉积胶原和其他细胞外基质成分。从历史上看，严重的纤维增生性肺疾病的发展与预后不良、高死亡率和/或长时间的呼吸机依赖有关。最近的研究也支持纤维增殖反应的大小与长期健康相关的生活质量之间的关系。决定哪些患者发生纤维增生性ARDS的因素以及导致这种病理反应的细胞机制尚不清楚。本文就肺功能障碍对ARDS存活者死亡率和生活质量的影响、导致病理性纤维增殖的机制以及预防或减轻纤维增生性肺疾病的潜在治疗方法的研究进展作一综述。
Acute respiratory distress syndrome (ARDS) continues to be a major healthcare problem, affecting >190 000 people in the USA annually, with a mortality of 27–45%, depending on the severity of the illness and comorbidities. Despite advances in clinical care, particularly lung protective strategies of mechanical ventilation, most survivors experience impaired health-related quality of life for years after the acute illness. While most patients survive the acute illness, a subset of ARDS survivors develops a fibroproliferative response characterised by fibroblast accumulation and deposition of collagen and other extracellular matrix components in the lung. Historically, the development of severe fibroproliferative lung disease has been associated with a poor prognosis with high mortality and/or prolonged ventilator dependence. More recent studies also support a relationship between the magnitude of the fibroproliferative response and long-term health-related quality of life. The factors that determine which patients develop fibroproliferative ARDS and the cellular mechanisms responsible for this pathological response are not well understood. This article reviews our current understanding of the contribution of pulmonary dysfunction to mortality and to quality of life in survivors of ARDS, the mechanisms driving pathological fibroproliferation and potential therapeutic approaches to prevent or attenuate fibroproliferative lung disease.
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影响因子：
8.8
作者：
Burnham EL;Hyzy RC;Paine R 3rd;Coley C 2nd;Kelly AM;Quint LE;Lynch D;Janssen WJ;Moss M;Standiford TJ
通讯作者：
Standiford TJ
DOI：
10.3109/08977194.2011.595714
发表时间：
2011-10
期刊：
Growth factors (Chur, Switzerland)
影响因子：
--
作者：
Biernacka A;Dobaczewski M;Frangogiannis NG
通讯作者：
Frangogiannis NG
DOI：
10.1164/rccm.201103-0503oc
发表时间：
2012-03-01
影响因子：
24.7
作者：
Bienvenu, Oscar J.;Colantuoni, Elizabeth;Needham, Dale M.
通讯作者：
Needham, Dale M.
影响因子：
158.5
作者：
Herridge, Margaret S.;Tansey, Catherine M.;Cheung, Angela M.
通讯作者：
Cheung, Angela M.
影响因子：
19.7
作者：
Desai, SR;Wells, AU;Hansell, DM
通讯作者：
Hansell, DM