A meta-analysis on the uncinate fasciculus in depression.
A meta-analysis on the uncinate fasciculus in depression.
复制标题
抑郁症患者钩束的Meta分析。
DOI：
10.1017/s0033291723000107
复制
发表时间：
2023-05
影响因子：
6.9
通讯作者：
Linke, Julia O. O.
中科院分区：
文献类型：
--
作者：
Xu, Ellie P. P.;Nguyen, Lynn;Leibenluft, Ellen;Stange, Jonathan P. P.;Linke, Julia O. O.
关键词：
钩束(UNC)是一种与情绪调节有关的白质束，其异常微结构被认为是抑郁症的一种神经生物学机制。然而，检验这一假设的研究得出了不一致的结果。目前的Meta分析巩固了44项研究的证据，比较了抑郁症患者(n=5016)和健康人(n=18425)的UNC的分数各向异性(FA)和径向弥散率(RD)，这两个指标描述了WM的微观结构。我们进行元回归以确定在北卡罗来纳大学的研究结果中导致交叉研究异质性的人口学和临床特征。与健康人相比，抑郁症患者的UNC FA降低。在抑郁症患者和健康人之间，UNC-RD具有可比性。在北卡罗来纳大学的研究结果中，共病焦虑解释了研究间的异质性。凹陷与UNC微观结构的扰动有关，特别是关于UNC FA而不是UNC RD。抑郁和UNC微观结构之间的联系似乎受到焦虑的影响。未来的工作将揭开抑郁症中UNC微结构异常的细胞机制；澄清UNC微结构、抑郁和焦虑之间的关系；并将UNC微结构与心理过程联系起来，如情绪调节。
Aberrant microstructure of the uncinate fasciculus (UNC), a white matter (WM) tract implicated in emotion regulation, has been hypothesized as a neurobiological mechanism of depression. However, studies testing this hypothesis have yielded inconsistent results. The present meta-analysis consolidates evidence from 44 studies comparing fractional anisotropy (FA) and radial diffusivity (RD), two metrics characterizing WM microstructure, of the UNC in individuals with depression (n = 5016) to healthy individuals (n = 18 425). We conduct meta-regressions to identify demographic and clinical characteristics that contribute to cross-study heterogeneity in UNC findings. UNC FA was reduced in individuals with depression compared to healthy individuals. UNC RD was comparable between individuals with depression and healthy individuals. Comorbid anxiety explained inter-study heterogeneity in UNC findings. Depression is associated with perturbations in UNC microstructure, specifically with respect to UNC FA and not UNC RD. The association between depression and UNC microstructure appears to be moderated by anxiety. Future work should unravel the cellular mechanisms contributing to aberrant UNC microstructure in depression; clarify the relationship between UNC microstructure, depression, and anxiety; and link UNC microstructure to psychological processes, such as emotion regulation.
影响因子：
3.1
作者：
Liu Z;Kang L;Zhang A;Yang C;Liu M;Wang J;Liu P;Zhang K;Sun N
通讯作者：
Sun N
DOI：
10.1016/j.nicl.2021.102574
发表时间：
2021
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Kochunov P;Ryan MC;Yang Q;Hatch KS;Zhu A;Thomopoulos SI;Jahanshad N;Schmaal L;Thompson PM;Chen S;Du X;Adhikari BM;Bruce H;Hare S;Goldwaser EL;Kvarta MD;Nichols TE;Hong LE
通讯作者：
Hong LE
影响因子：
6.6
作者：
Yuen GS;Gunning FM;Woods E;Klimstra SA;Hoptman MJ;Alexopoulos GS
通讯作者：
Alexopoulos GS