Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder.
Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder.
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DOI：
10.1155/2021/2348072
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发表时间：
2021
影响因子：
3.1
通讯作者：
Sun N
中科院分区：
文献类型：
--
作者：
Liu Z;Kang L;Zhang A;Yang C;Liu M;Wang J;Liu P;Zhang K;Sun N
目前，重性抑郁症（MDD）的病因和发病机制尚不清楚。研究发现，MDD一级亲属的患病风险是普通人群的2-3倍。弥散张量成像（DTI）以前已被用于探讨MDD的发病机制。本研究旨在通过DTI技术探讨MDD的病因，并进一步探讨其临床特征与脑内白色物质结构改变的相关性。该研究包括27名首次发作的药物初治MDD患者，16名无MDD的一级亲属和28名无MDD家族史的健康对照受试者（HC）。结果显示，各组间各向异性分数（FA）的差异主要在丘脑左前放射（LATR）、丘脑右前放射（RATR）、皮质脊髓束（LCST）、大钳束（FMa）、右下纵束（RILF）和左上级纵束（颞）（LSLF（T））。在6个位点中，LCST、FMa和LSLF（T）在MDD和一级亲属之间与HC相比具有显著差异。MDD患者有明显的情绪症状、躯体症状和认知障碍。FMa FA与延迟记忆评分呈显著正相关（r = 0.43，P = 0.031），RILF FA与FSS评分呈显著负相关（r =-0.42，P = 0.028）。提示MDD易感患者的白色特征为LCST、FMa和LSLF（T）病变，这些病变可能是MDD的质量指标。
At present, the etiology and pathogenesis of major depressive disorder (MDD) are still not clear. Studies have found that the risk of first-degree relatives of MDD is 2–3 times that of the general population. Diffusion tensor imaging (DTI) has been previously used to explore the pathogenesis of MDD. The purpose of this study is to explore the etiology of MDD by DTI and further to explore the correlation between its clinical characteristics and the structural changes of white matter in the brain. The study included 27 first-episode, drug-naive patients with MDD, 16 first-degree relatives without MDD, and 28 healthy control subjects with no family history of MDD (HC). Results showed that the fractional anisotropy (FA) differences among the three groups were mainly in the left anterior thalamic radiation (LATR), right anterior thalamic radiation (RATR), left corticospinal tracts (LCST), forceps major (FMa), right inferior longitudinal fasciculus (RILF), and left superior longitudinal fasciculus (temporal) (LSLF(T)). Among the 6 sites, LCST, FMa, and LSLF(T) showed significant differences between MDD and First-degree relatives compared to HC. MDD patients had significant emotional symptoms, somatic symptoms, and cognitive impairment. FMa FA was significantly positively correlated with delayed memory score (r = 0.43, P = 0.031), and RILF FA was significantly negatively correlated with the FSS score (r = −0.42, P = 0.028). These results revealed that the white matter characteristics of MDD-susceptible patients were LCST, FMa, and LSLF(T) lesions, all of which may be quality indicators of MDD.
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影响因子：
3.3
作者：
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通讯作者：
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