The Role of Inflammation in Age-Related Macular Degeneration.
The Role of Inflammation in Age-Related Macular Degeneration.
复制标题
炎症在年龄相关性黄斑变性中的作用。
DOI：
10.7150/ijbs.49890
复制
发表时间：
2020
影响因子：
9.2
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Tan W;Zou J;Yoshida S;Jiang B;Zhou Y
视网膜相关性黄斑变性（AMD）是一种致盲性眼病，其发病率随着年龄的增长而逐渐增加。炎症参与AMD的发病机制，包括脉络膜新生血管和地图样萎缩。这也是一种自我保护的调节，使眼睛免受伤害。本文综述了炎症在AMD发病机制中的作用，并对炎症相关细胞因子（包括促炎细胞因子和抗炎细胞因子）以及白细胞（巨噬细胞、树突状细胞、中性粒细胞、T淋巴细胞和B淋巴细胞）在AMD先天性或获得性免疫中的作用进行了综述。还讨论了可能的临床应用，例如潜在的诊断生物标志物和抗炎疗法。本文综述了炎症作为治疗AMD的新的有效治疗方法的目标。
Age-related macular degeneration (AMD) is a blinding eye disease which incidence gradually increases with age. Inflammation participates in AMD pathogenesis, including choroidal neovascularization and geographic atrophy. It is also a kind of self-protective regulation from injury for the eyes. In this review, we described inflammation in AMD pathogenesis, summarized the roles played by inflammation-related cytokines, including pro-inflammatory and anti-inflammatory cytokines, as well as leukocytes (macrophages, dendritic cells, neutrophils, T lymphocytes and B lymphocytes) in the innate or adaptive immunity in AMD. Possible clinical applications such as potential diagnostic biomarkers and anti-inflammatory therapies were also discussed. This review overviews the inflammation as a target of novel effective therapies in treating AMD.
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影响因子：
15.8
作者：
Apte, Rajendra S.;Richter, Jennifer;Herndon, John;Ferguson, Thomas A.
通讯作者：
Ferguson, Thomas A.
影响因子：
--
作者：
Bandello F;Sacconi R;Querques L;Corbelli E;Cicinelli MV;Querques G
通讯作者：
Querques G
DOI：
10.1016/j.omtm.2020.01.006
发表时间：
2020-06-12
影响因子：
4.7
作者：
Chung, Sook Hyun;Mollhoff, Iris Natalie;Yiu, Glenn
通讯作者：
Yiu, Glenn
影响因子：
13.7
作者：
Colijn JM;Buitendijk GHS;Prokofyeva E;Alves D;Cachulo ML;Khawaja AP;Cougnard-Gregoire A;Merle BMJ;Korb C;Erke MG;Bron A;Anastasopoulos E;Meester-Smoor MA;Segato T;Piermarocchi S;de Jong PTVM;Vingerling JR;Topouzis F;Creuzot-Garcher C;Bertelsen G;Pfeiffer N;Fletcher AE;Foster PJ;Silva R;Korobelnik JF;Delcourt C;Klaver CCW;EYE-RISK consortium;European Eye Epidemiology (E3) consortium
通讯作者：
European Eye Epidemiology (E3) consortium
DOI：
10.1016/j.jphotobiol.2016.05.018
发表时间：
2016-08-01
影响因子：
5.4
作者：
Brandstetter, Carolina;Patt, Joshua;Krohne, Tim U.
通讯作者：
Krohne, Tim U.