Wnt5a Signaling in Cancer.
Wnt5a Signaling in Cancer.
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DOI：
10.3390/cancers8090079
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发表时间：
2016-08-26
期刊：
影响因子：
5.2
通讯作者：
Stack MS
中科院分区：
文献类型：
--
作者：
Asem MS;Buechler S;Wates RB;Miller DL;Stack MS
Wnt5a is involved in activating several non-canonical WNT signaling pathways, through binding to different members of the Frizzled- and Ror-family receptors. Wnt5a signaling is critical for regulating normal developmental processes, including proliferation, differentiation, migration, adhesion and polarity. However, the aberrant activation or inhibition of Wnt5a signaling is emerging as an important event in cancer progression, exerting both oncogenic and tumor suppressive effects. Recent studies show the involvement of Wnt5a in regulating cancer cell invasion, metastasis, metabolism and inflammation. In this article, we review findings regarding the molecular mechanisms and roles of Wnt5a signaling in various cancer types, and highlight Wnt5a in ovarian cancer.
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影响因子：
11.2
作者：
Borcherding N;Kusner D;Kolb R;Xie Q;Li W;Yuan F;Velez G;Askeland R;Weigel RJ;Zhang W
通讯作者：
Zhang W
影响因子：
4.4
作者：
Bergenfelz, Caroline;Medrek, Catharina;Leandersson, Karin
通讯作者：
Leandersson, Karin
DOI：
10.1042/bj20110112
发表时间：
2011-07-01
期刊：
The Biochemical journal
影响因子：
--
作者：
Barbolina MV;Burkhalter RJ;Stack MS
通讯作者：
Stack MS
DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
CAMPISI, J
影响因子：
4.8
作者：
Burkhalter, Rebecca J.;Westfall, Suzanne D.;Stack, M. Sharon
通讯作者：
Stack, M. Sharon