Beneficial effect of Bupleurum polysaccharides on autoimmune-prone MRL-lpr mice.
Beneficial effect of Bupleurum polysaccharides on autoimmune-prone MRL-lpr mice.
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DOI：
10.1155/2012/842928
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发表时间：
2012
影响因子：
--
通讯作者：
Chen DF
中科院分区：
文献类型：
--
作者：
Jiang YW;Li H;Zhang YY;Li W;Jiang YF;Ou YY;Chen DF
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease leading to inflammatory tissue damage in multiple organs. The crude polysaccharides (BPs) isolated from the roots of Bupleurum smithii var. parvifolium have anticomplementary activity and immunomodulatory functions on macrophages. To study its potential benefit on SLE, we examined effects of BPs on MRL-lpr mice, which have similar disease features to human SLE. MRL-lpr mice were treated orally with BPs 15, 30, or 60 mg kg−1 day−1 for 12 weeks and their SLE characteristics were evaluated. The results revealed that BPs elongated life span, improved kidney function, delayed lymphadenopathy, and reduced autoantibodies. It seemed to be mediated by inhibition of complement and macrophages activation and suppression of interferon-γ (IFN-γ) and interleukin-6 (IL-6) gene expression in the kidney. These results implicate that BPs may be an immunomodulator for the treatment of autoimmune diseases like SLE.
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影响因子：
6.1
作者：
Navarro, P;Giner, RM;Ríos, JL
通讯作者：
Ríos, JL
影响因子：
15.3
作者：
BIESECKER, G;KATZ, S;KOFFLER, D
通讯作者：
KOFFLER, D
影响因子：
5.4
作者：
Cheng, Xiao-Qin;Li, Hong;Chen, Dao-Feng
通讯作者：
Chen, Dao-Feng
影响因子：
32.4
作者：
Jego, G;Palucka, AK;Banchereau, J
通讯作者：
Banchereau, J
影响因子：
4.4
作者：
Hoi, Alberta Y.;Hickey, Michael J.;Morand, Eric F.
通讯作者：
Morand, Eric F.