Modification of depression by COMT val158met polymorphism in children exposed to early severe psychosocial deprivation.
Modification of depression by COMT val158met polymorphism in children exposed to early severe psychosocial deprivation.
复制标题
DOI：
10.1016/j.chiabu.2009.09.021
复制
发表时间：
2010-06
影响因子：
4.8
通讯作者：
Zeanah CH
中科院分区：
文献类型：
--
作者：
Drury SS;Theall KP;Smyke AT;Keats BJ;Egger HL;Nelson CA;Fox NA;Marshall PJ;Zeanah CH
To examine the impact of the Catechol-O-Methyltransferase (COMT) val158met allele on depressive symptoms in young children exposed to early severe social deprivation as a result of being raised in institutions. 136 children from the Bucharest Early Intervention Project (BEIP) were randomized before 31 months of age to either care as usual (CAU) in institutions or placement in newly created foster care (FCG). At 54 months of age, a psychiatric assessment using the Preschool Age Psychiatric Assessment (PAPA) was completed. DNA was collected and genotyped for the COMT val158met polymorphism. Multivariate analysis examined the relationship between COMT alleles and depressive symptoms. Mean level of depressive symptoms was lower among participants with the met allele compared to those with two copies of the val allele (p <0.05). Controlling for group and gender, the rate of depressive symptoms was significantly lower among participants with the met/met or the met/val genotype (adjusted relative risk (aRR) = 0.67, 95% CI = 0.45, 0.99) compared to participants with the val/val genotype, indicating an intermediate impact for heterozygotes consistent with the biological impact of this polymorphism. The impact of genotype within groups differed significantly. There was a significant protective effect of the met allele on depressive symptoms within the CAU group, however there was no relationship seen within the FCG group. This is the first study, to our knowledge, to find evidence of a gene × environment interaction in the setting of early social deprivation. These results support the hypothesis that individual genetic differences may explain some of the variability in recovery amongst children exposed to early severe social deprivation.
登录
查看更多内容
影响因子：
3.7
作者：
Diamond, Adele
通讯作者：
Diamond, Adele
影响因子：
10.6
作者：
Kaufman, J;Yang, BZ;Gelernter, J
通讯作者：
Gelernter, J
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
17.7
作者：
Diamond, A;Briand, L;Gehlbach, L
通讯作者：
Gehlbach, L
影响因子：
22.4
作者：
Hutchison, KE;Stallings, M;Bryan, A
通讯作者：
Bryan, A