Cardiac tissue structure, properties, and performance: a materials science perspective.

Cardiac tissue structure, properties, and performance: a materials science perspective.
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心脏组织结构,特性和性能:材料科学的观点。

DOI:
10.1007/s10439-014-1071-z
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发表时间:
2014-10
影响因子:
3.8
通讯作者:
Chesler, Naomi C.
Chesler, Naomi C.
中科院分区:
工程技术2区
文献类型:
--
作者:
Golob, Mark;Moss, Richard L.;Chesler, Naomi C.

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从工程学的角度来看,许多形式的心脏病可以被认为是生物材料性能的降低,其中生物材料是包括心室壁的组织。在材料科学中,材料的结构和性质被认为与性能相互关联。此外,对于大多数结构、性质和性能的测量,需要进行一些处理。在这里,我们回顾了目前的知识状态,心脏组织的结构,属性和性能,以及采取的处理步骤,以获得这些测量。了解这些因素的影响及其相互作用可能会增强我们对心脏功能和心力衰竭的理解。我们还审查了心脏组织性质和性能测量的设计考虑因素,因为迄今为止,大多数心脏组织数据是在非生理负荷条件下获得的。考虑到这些设计考虑因素的新型测量系统可能会改善未来的实验,并导致对心脏组织结构,特性和最终性能的更深入了解。
From an engineering perspective, many forms of heart disease can be thought of as a reduction in biomaterial performance, in which the biomaterial is the tissue comprising the ventricular wall. In materials science, the structure and properties of a material are recognized to be interconnected with performance. In addition, for most measurements of structure, properties, and performance, some processing is required. Here, we review the current state of knowledge regarding cardiac tissue structure, properties, and performance as well as the processing steps taken to acquire those measurements. Understanding the impact of these factors and their interactions may enhance our understanding of heart function and heart failure. We also review design considerations for cardiac tissue property and performance measurements because, to date, most data on cardiac tissue has been obtained under non-physiological loading conditions. Novel measurement systems that account for these design considerations may improve future experiments and lead to greater insight into cardiac tissue structure, properties, and ultimately performance.
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