Risk of Metabolic Syndrome in Kidney Stone Formers: A Comparative Cohort Study with a Median Follow-Up of 19 Years.
Risk of Metabolic Syndrome in Kidney Stone Formers: A Comparative Cohort Study with a Median Follow-Up of 19 Years.
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DOI：
10.3390/jcm10050978
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发表时间：
2021-03-02
影响因子：
3.9
通讯作者：
Somani B
中科院分区：
文献类型：
--
作者：
Geraghty RM;Cook P;Roderick P;Somani B
背景资料：肾结石形成者（SF）更容易发展为糖尿病（DM），但尚无研究检查该人群中代谢综合征（MetS）的风险。我们的目的是描述与非SF相比，SF中MetS的风险。方法和材料：SF指的是1990年至2007年在英格兰南部的三级转诊代谢中心，对照患者的年龄、性别和时期（首次结石）匹配，比例为3：1，来自同一初级保健数据库。排除无文件记录或既往MetS的SF。获得伦理批准，并使用修改后的美国临床内分泌学家协会（AACE）标准定义MetS。考克斯比例风险回归分析。结果：在筛选了1000份记录后，共纳入828份SF，2484份年龄和性别匹配的非SF对照品。结石形成者和无结石对照者的中位随访时间为19年（四分位数范围-IQR：15-22）。SF发生MetS的风险显著增加（风险比HR：1.77; 95%置信区间CI：1.55-2.03，p < 0.001）。该效应对于调整既存组分具有稳健性（HR：1.91; 95% CI：1.66-2.19，p < 0.001）。结论：肾结石患者发生代谢综合征的风险增加。鉴于病理生理机制，结石很可能是潜在代谢异常的“症状”，无论是隐性的还是显性的。这意味着进一步结石事件和心血管疾病的风险。
Background: Kidney stone formers (SF) are more likely to develop diabetes mellitus (DM), but there is no study examining risk of metabolic syndrome (MetS) in this population. We aimed to describe the risk of MetS in SF compared to non-SF. Methods and Materials: SF referred to a tertiary referral metabolic centre in Southern England from 1990 to 2007, comparator patients were age, sex, and period (first stone) matched with 3:1 ratio from the same primary care database. SF with no documentation or previous MetS were excluded. Ethical approval was obtained and MetS was defined using the modified Association of American Clinical Endocrinologists (AACE) criteria. Analysis with cox proportional hazard regression. Results: In total, 828 SF were included after 1000 records were screened for inclusion, with 2484 age and sex matched non-SF comparators. Median follow-up was 19 years (interquartile range—IQR: 15–22) for both stone formers and stone-free comparators. SF were at significantly increased risk of developing MetS (hazard ratio—HR: 1.77; 95% confidence interval—CI: 1.55–2.03, p < 0.001). This effect was robust to adjustment for pre-existing components (HR: 1.91; 95% CI: 1.66–2.19, p < 0.001). Conclusions: Kidney stone formers are at increased risk of developing metabolic syndrome. Given the pathophysiological mechanism, the stone is likely a ‘symptom’ of an underlying metabolic abnormality, whether covert or overt. This has implications the risk of further stone events and cardiovascular disease.
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影响因子：
64.5
作者：
Jiang L;Wang M;Lin S;Jian R;Li X;Chan J;Dong G;Fang H;Robinson AE;GTEx Consortium;Snyder MP
通讯作者：
Snyder MP
影响因子：
3.7
作者：
Oh, Seung-Won;Lee, Jong-Eun;Choi, Seung Ho
通讯作者：
Choi, Seung Ho
DOI：
10.2215/cjn.06600616
发表时间：
2017-03-01
影响因子：
9.8
作者：
Kittanamongkolchai, Wonngarm;Mara, Kristin C.;Rule, Andrew D.
通讯作者：
Rule, Andrew D.
影响因子：
--
作者：
Daudon, M;Lacour, B;Jungers, P
通讯作者：
Jungers, P
DOI：
10.1152/ajprenal.00550.2007
发表时间：
2008-06-01
影响因子：
4.2
作者：
Bobulescu, I. Alexandru;Dubree, Michele;Moe, Orson W.
通讯作者：
Moe, Orson W.