Poststroke arm and hand paresis: should we target the cervical spinal cord?

Poststroke arm and hand paresis: should we target the cervical spinal cord?
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中风后手臂和手部麻痹:我们应该针对颈脊髓吗?

DOI:
10.1016/j.tins.2022.05.002
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发表时间:
2022
影响因子:
15.9
通讯作者:
Capogrosso,Marco
Capogrosso,Marco
中科院分区:
医学1区
文献类型:
--
作者:
Pirondini,Elvira;Carranza,Erick;Balaguer,Josep-Maria;Sorensen,Erynn;Weber,DouglasJ;Krakauer,JohnW;Capogrosso,Marco

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尽管对皮质脊髓运动控制和卒中病理生理学的理解取得了进展,但目前卒中后上肢轻瘫的康复治疗在损伤水平上的疗效有限。为了解决这个问题,我们提出了一种新的治疗方法的概念。我们首先总结了目前对中风后手臂和手部运动控制缺陷的理解,以及它们与脊髓损伤(SCI)的共同生理机制。然后,我们回顾了脊髓刺激(SCS)恢复SCI后的运动能力的研究,这些研究为增强残余皮质脊髓功能提供了令人信服的证据。通过外推,我们主张使用颈部脊髓刺激恢复中风后上肢运动控制。
Despite advances in understanding of corticospinal motor control and stroke pathophysiology, current rehabilitation therapies for poststroke upper limb paresis have limited efficacy at the level of impairment. To address this problem, we make the conceptual case for a new treatment approach. We first summarize current understanding of motor control deficits in the arm and hand after stroke and their shared physiological mechanisms with spinal cord injury (SCI). We then review studies of spinal cord stimulation (SCS) for recovery of locomotion after SCI, which provide convincing evidence for enhancement of residual corticospinal function. By extrapolation, we argue for using cervical SCS to restore upper limb motor control after stroke.
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