Modic changes-Their associations with low back pain and activity limitation: A systematic literature review and meta-analysis.
Modic changes-Their associations with low back pain and activity limitation: A systematic literature review and meta-analysis.
复制标题
与腰痛和活动限制的敏捷性变化相关：系统文献综述和荟萃分析。
DOI：
10.1371/journal.pone.0200677
复制
发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Jensen TS
中科院分区：
文献类型：
--
作者：
Herlin C;Kjaer P;Espeland A;Skouen JS;Leboeuf-Yde C;Karppinen J;Niinimäki J;Sørensen JS;Storheim K;Jensen TS
先前的系统评价已报道 Modic 变化 (MC) 与腰痛 (LBP) 之间的正相关关系，但由于其范围狭窄和新的初步研究，需要进行全面的系统评价。我们的目标是调查 MC 是否与非特异性 LBP 和/或活动限制相关，以及这种关联是否会受到其他因素的影响。在开始工作之前，本次审查的方案已在 PROSPERO 注册（PROSPERO 记录：CRD42015017350）。在 MEDLINE、CINAHL 和 EMBASE 数据库中检索了从第一个记录到 2016 年 6 月 15 日的相关研究。前瞻性或回顾性横断面队列研究和病例对照研究，包括来自普通、工作和临床研究人群的所有年龄段的人，都有资格纳入。偏倚风险评估以及关联和潜在修饰因素的数据提取由一对评审员独立完成。对同质研究进行荟萃分析，并以比值比 (OR) 表示，置信区间为 95%。总共确定了 5210 次引用，纳入了 31 项研究。一项研究的偏倚风险较低。 15 项研究 (48%) 报告了 MC 和 LBP 之间存在统计学上显着的正相关性，而一项研究发现了统计学上显着的负相关性。使用一致疼痛与刺激性椎间盘造影作为临床结果的研究进行荟萃分析，得出 OR 为 4.01 (1.52–10.61)。七项研究中有一项报告了 MC 与活动限制之间存在统计学上显着的正相关关系。研究发现腰椎间盘水平和椎间盘退变会改变 MC 和 LBP 之间的关联。这项全面系统评价的结果表明，MC 与 LBP 相关结果之间的关联并不一致。研究样本、临床结果以及 MC 和 LBP 患病率估计方面的高偏倚风险和异质性可能可以解释这些发现。低偏倚风险的新研究很可能会影响这些关联的方向和强度。
Previous systematic reviews have reported positive associations between Modic changes (MCs) and low back pain (LBP), but due to their narrow scope and new primary studies, there is a need for a comprehensive systematic review. Our objectives were to investigate if MCs are associated with non-specific LBP and/or activity limitation and if such associations are modified by other factors. A protocol for this review was registered at PROSPERO prior to commencing the work (PROSPERO record: CRD42015017350). The MEDLINE, CINAHL and EMBASE databases were searched for relevant studies from first record to June 15th 2016. Prospective or retrospective cross-sectional cohort studies and case-control studies including people of all ages from general, working and clinical study populations were eligible for inclusion. Risk of bias assessment and data extraction for associations and potential modifiers were completed independently by pairs of reviewers. Meta-analysis was performed for homogeneous studies and presented as odds ratios (OR) with 95% CI. In all, 5210 citations were identified and 31 studies were included. One study had low risk of bias. Fifteen studies (48%) reported statistically significant positive associations between MCs and LBP and one study found a statistically significant negative association. Meta-analysis performed for studies using concordant pain with provocative discography as the clinical outcome resulted in an OR of 4.01 (1.52–10.61). One of seven studies reported a statistically significant positive association between MCs and activity limitation. Lumbar disc level and disc degeneration were found to modify the association between MCs and LBP. The results from this comprehensive systematic review indicate that the associations between MCs and LBP-related outcomes are inconsistent. The high risk of bias and the heterogeneity in terms of study samples, clinical outcomes and prevalence estimates of MCs and LBP may explain these findings. It is likely that new studies with low risk of bias will affect the direction and strength of these associations.
登录
查看更多内容
影响因子：
3
作者：
Ito, M;Incorvaia, KM;Rosenbaum, AE
通讯作者：
Rosenbaum, AE
影响因子：
3
作者：
Chou, Dean;Samartzis, Dino;Skelly, Andrea C.
通讯作者：
Skelly, Andrea C.
影响因子：
4.7
作者：
Albert, H. B.;Kjaer, P.;Manniche, Claus
通讯作者：
Manniche, Claus
DOI：
10.1016/j.spinee.2004.05.250
发表时间：
2005-01-01
期刊：
The spine journal : official journal of the North American Spine Society
影响因子：
--
作者：
Carragee, Eugene J;Alamin, Todd F;Carragee, John M
通讯作者：
Carragee, John M
DOI：
10.1115/1.4024828
发表时间：
2013-09-01
影响因子：
1.7
作者：
Jamison, David;Cannella, Marco;Marcolongo, Michele S.
通讯作者：
Marcolongo, Michele S.