Elements of the cellular metabolic structure.
Elements of the cellular metabolic structure.
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细胞代谢结构的元素。
DOI：
10.3389/fmolb.2015.00016
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发表时间：
2015
影响因子：
5
通讯作者：
De la Fuente IM
中科院分区：
文献类型：
--
作者：
De la Fuente IM
大量的研究已经证明了在不同的分子结构中存在代谢共价修饰，这些修饰能够存储非由DNA编码的生化信息。这些共价标记模式中的一些可以跨代传递（表观遗传变化）。最近，Hopfield吸引动力学的出现已被观察到在自组织的酶网络，它有能力存储功能的催化模式，可以正确地恢复特定的输入刺激。Hopfield样代谢动力学是稳定的，可以作为长期的生化记忆保持。此外，特定的分子信息可以从代谢网络的功能动力学转移到参与共价翻译后调节的酶活性，从而确定的功能记忆可以嵌入多个稳定的分子标记中。由Hopfield型吸引子（功能过程）控制的代谢动力学以及特定分子的酶促共价修饰（结构动力学过程）似乎代表了细胞代谢的动态记忆（代谢记忆）的两个阶段。表观遗传过程似乎是这种细胞代谢记忆的结构表现。在这里，提出了一个新的框架，在细胞中的分子信息存储，其特征在于由两个功能和分子相互关联的系统：一个动态的，灵活的和自适应的系统（代谢记忆）和一个基本上保守的系统（遗传记忆）。两个系统的分子信息似乎协调整个细胞的生理发育。
A large number of studies have demonstrated the existence of metabolic covalent modifications in different molecular structures, which are able to store biochemical information that is not encoded by DNA. Some of these covalent mark patterns can be transmitted across generations (epigenetic changes). Recently, the emergence of Hopfield-like attractor dynamics has been observed in self-organized enzymatic networks, which have the capacity to store functional catalytic patterns that can be correctly recovered by specific input stimuli. Hopfield-like metabolic dynamics are stable and can be maintained as a long-term biochemical memory. In addition, specific molecular information can be transferred from the functional dynamics of the metabolic networks to the enzymatic activity involved in covalent post-translational modulation, so that determined functional memory can be embedded in multiple stable molecular marks. The metabolic dynamics governed by Hopfield-type attractors (functional processes), as well as the enzymatic covalent modifications of specific molecules (structural dynamic processes) seem to represent the two stages of the dynamical memory of cellular metabolism (metabolic memory). Epigenetic processes appear to be the structural manifestation of this cellular metabolic memory. Here, a new framework for molecular information storage in the cell is presented, which is characterized by two functionally and molecularly interrelated systems: a dynamic, flexible and adaptive system (metabolic memory) and an essentially conservative system (genetic memory). The molecular information of both systems seems to coordinate the physiological development of the whole cell.
影响因子：
4
作者：
Kamimura A;Kobayashi TJ
通讯作者：
Kobayashi TJ