Information processing and integration with intracellular dynamics near critical point.
Information processing and integration with intracellular dynamics near critical point.
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DOI：
10.3389/fphys.2012.00203
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发表时间：
2012
影响因子：
4
通讯作者：
Kobayashi TJ
中科院分区：
文献类型：
--
作者：
Kamimura A;Kobayashi TJ
最近的实验观察表明，即使信号中不可避免地包含大量噪声，细胞也可以对外部信号显示出相对精确和可靠的响应。一个有趣的问题是细胞是如何做到这一点的，一个可能的方法是进化发展和优化细胞内的信号通路，以便从嘈杂的信号中提取相关信息。我们最近证明，某些细胞内信号反应实际上可以进行统计学上最优的信息处理。在本文中，我们澄清，这样的最优反应的分歧点附近的工作。这一结果表明，单细胞水平上的临界现象可能与细胞内的有效信息处理有关。此外，提高单细胞水平的响应性能并不是细胞实现可靠响应的唯一途径。另一种可能的策略是通过细胞与细胞的相互作用，如群体感应，整合单个细胞的信息。由于细胞间相互作用是一种常见的现象，因此研究细胞如何通过细胞间相互作用整合其信息以实现群体水平的有效信息处理同样重要。在本文中，我们考虑的作用和好处的细胞与细胞之间的相互作用，考虑从信息处理的观点与其他细胞的个人所获得的信息的整合。我们还表明，通过引入细胞运动，空间组织可以自发地出现作为人口对外部信号的有效响应的结果。
Recent experimental observations suggest that cells can show relatively precise and reliable responses to external signals even though substantial noise is inevitably involved in the signals. An intriguing question is the way how cells can manage to do it. One possible way to realize such response for a cell is to evolutionary develop and optimize its intracellular signaling pathways so as to extract relevant information from the noisy signal. We recently demonstrated that certain intracellular signaling reactions could actually conduct statistically optimal information processing. In this paper, we clarify that such optimal reaction operates near bifurcation point. This result suggests that critical-like phenomena in the single-cell level may be linked to efficient information processing inside a cell. In addition, improving the performance of response in the single-cell level is not the only way for cells to realize reliable response. Another possible strategy is to integrate information of individual cells by cell-to-cell interaction such as quorum sensing. Since cell-to-cell interaction is a common phenomenon, it is equally important to investigate how cells can integrate their information by cell-to-cell interaction to realize efficient information processing in the population level. In this paper, we consider roles and benefits of cell-to-cell interaction by considering integrations of obtained information of individuals with the other cells from the viewpoint of information processing. We also demonstrate that, by introducing cell movement, spatial organizations can spontaneously emerge as a result of efficient responses of the population to external signals.
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