Outpatient follow-up of patients hospitalized for acute leptospirosis.
Outpatient follow-up of patients hospitalized for acute leptospirosis.
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DOI：
10.1016/j.ijid.2011.03.020
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发表时间：
2011-07
影响因子：
8.4
通讯作者：
Vinetz, Joseph M.
中科院分区：
文献类型：
--
作者：
Spichler, Anne;Athanazio, Daniel;Seguro, Antonio C.;Vinetz, Joseph M.
钩端螺旋体病急性疾病消退后的结局，无论是自发的还是治疗后的，都没有很好的描述。本研究的目的是评估急性钩端螺旋体病出院后可能的后遗症。我们在这里报告了一项在巴西圣保罗进行的前瞻性研究，在该研究中，门诊随访了因钩端螺旋体病住院的患者。对47例患者进行了系列评估：32例重度和15例轻度病例。早期和晚期并发症在两组中均不常见，但出院后最初几周内主观主诉常见（53%的重度病例，40%的轻度病例）。两名患者有持续的投诉：一个有深刻的全身不适，另一个发展为新发恐慌症。分析的样本代表了研究期间圣保罗市26%的钩端螺旋体病住院患者。第一次访视的平均随访时间约为20天，第二次访视的平均随访时间约为40天。47名患者接受了一次随访，其中22名患者接受了两次随访。虽然47例患者中有2例报告急性钩端螺旋体病住院后症状持续，但没有明确的客观证据证明这种感染导致慢性后遗症。虽然是初步的，但这些观察结果表明需要进行前瞻性、严格和系统的研究，以明确确定和描述急性钩端螺旋体病后的晚期并发症和慢性疾病。
The outcome of leptospirosis after the resolution of acute disease, either spontaneously or after treatment, is not well described. The aim of this study was to assess the possible sequelae of acute leptospirosis after hospital discharge. We report here a prospective study carried out in São Paulo, Brazil in which patients hospitalized for leptospirosis were followed in the outpatient setting. Forty-seven patients were serially assessed: 32 severe and 15 mild cases. Early and late complications were not common in either group, but subjective complaints were common in the first few weeks after hospital discharge (53% of severe cases, 40% of mild cases). Two patients had continuing complaints: one had profound general malaise and the other developed new onset panic disorder. The sample analyzed represented 26% of the patients hospitalized with leptospirosis in the city of São Paulo during the study period. The duration of follow-up was an average of approximately 20 days at the first visit, and approximately 40 days at the second visit. Forty-seven patients came for one follow-up visit and 22 of the same patients had two follow-up visits. While two of 47 patients reported continuing symptoms after hospitalization for acute leptospirosis, no definitive, objective evidence of chronic sequelae due to this infection was proven. While preliminary, these observations point to the need for a prospective, rigorous and systematic study to definitively determine and characterize late complications and chronic disease after acute leptospirosis.
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DOI：
10.4269/ajtmh.2008.79.911
发表时间：
2008-12-01
影响因子：
3.3
作者：
Spichler, Anne S.;Vilaca, Pedro J.;Vinetz, Joseph M.
通讯作者：
Vinetz, Joseph M.
影响因子：
3.1
作者：
Ricaldi, Jessica N;Vinetz, Joseph M
通讯作者：
Vinetz, Joseph M
影响因子：
5.1
作者：
Panicker, JN;Mammachan, R;Jayakumar, RV
通讯作者：
Jayakumar, RV
影响因子：
4.2
作者：
Rathinam, SR;Rathnam, S;Namperumalsamy, P
通讯作者：
Namperumalsamy, P
影响因子：
6.1
作者：
Covic, A;Goldsmith, DJA;Covic, M
通讯作者：
Covic, M