A computational model of torque generation: neural, contractile, metabolic and musculoskeletal components.
A computational model of torque generation: neural, contractile, metabolic and musculoskeletal components.
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DOI：
10.1371/journal.pone.0056013
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Kent-Braun JA
中科院分区：
文献类型：
--
作者：
Callahan DM;Umberger BR;Kent-Braun JA
自主关节扭矩产生的途径包括运动神经元募集和速率编码、肌膜去极化和肌浆网释放钙、骨骼肌内运动蛋白产生的力以及肌腱穿过关节的力传递。这一过程的直接能量来源是ATP水解。有可能使用各种体内和体外技术来检查该生理途径的部分，但是最终影响关节扭矩的多个过程的综合视图仍然难以捉摸。为了解决这一差距，我们提出了一个全面的计算模型的组合神经肌肉和肌肉骨骼系统，包括新的组件相关的细胞内生物能量学功能。代表兴奋性驱动，肌肉激活，力的产生，代谢扰动和扭矩生产过程中自愿人类踝关节背屈的组件构建，使用实验得出的数据和文献值的组合。通过与体内获得的扭矩和代谢数据进行比较，验证了模拟结果。该模型成功地预测了峰值和次最大的自愿和电引起的扭矩输出，并准确地模拟了与自愿收缩相关的代谢扰动。这种新颖的，全面的模型可以用来更好地了解全球效应器，如年龄和疾病对神经肌肉系统的各个组成部分，并最终，自愿扭矩输出的影响。
The pathway of voluntary joint torque production includes motor neuron recruitment and rate-coding, sarcolemmal depolarization and calcium release by the sarcoplasmic reticulum, force generation by motor proteins within skeletal muscle, and force transmission by tendon across the joint. The direct source of energetic support for this process is ATP hydrolysis. It is possible to examine portions of this physiologic pathway using various in vivo and in vitro techniques, but an integrated view of the multiple processes that ultimately impact joint torque remains elusive. To address this gap, we present a comprehensive computational model of the combined neuromuscular and musculoskeletal systems that includes novel components related to intracellular bioenergetics function. Components representing excitatory drive, muscle activation, force generation, metabolic perturbations, and torque production during voluntary human ankle dorsiflexion were constructed, using a combination of experimentally-derived data and literature values. Simulation results were validated by comparison with torque and metabolic data obtained in vivo. The model successfully predicted peak and submaximal voluntary and electrically-elicited torque output, and accurately simulated the metabolic perturbations associated with voluntary contractions. This novel, comprehensive model could be used to better understand impact of global effectors such as age and disease on various components of the neuromuscular system, and ultimately, voluntary torque output.
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DOI：
10.1083/jcb.3.5.631
发表时间：
1957-09-25
期刊：
The Journal of biophysical and biochemical cytology
影响因子：
--
作者：
HUXLEY HE
通讯作者：
HUXLEY HE
影响因子：
5.5
作者：
Debold, E. P.;Beck, S. E.;Warshaw, D. M.
通讯作者：
Warshaw, D. M.
影响因子：
2.4
作者：
HAWKINS, DA;HULL, ML
通讯作者：
HULL, ML
影响因子：
64.8
作者：
HANSON, J;HUXLEY, HE
通讯作者：
HUXLEY, HE
影响因子：
5.5
作者：
GUSTAFSSON, B;PINTER, MJ
通讯作者：
PINTER, MJ