Immunopathogenesis of crescentic glomerulonephritis and lung purpura.
Immunopathogenesis of crescentic glomerulonephritis and lung purpura.
复制标题
新月体肾小球肾炎和肺紫癜的免疫发病机制。
DOI：
10.1038/ki.1987.225
复制
发表时间：
1987
影响因子：
19.6
通讯作者：
D. Salant
中科院分区：
文献类型：
--
作者：
D. Salant
一位61岁的白人妇女被转介到大学医院处理快速进展的肾小球肾炎和肺出血。入院前一周，患者出现咳嗽并伴有少量带血痰；在接下来的一周里，咳嗽和咯血变得更严重了。胸部x线显示双侧肺呈蝴蝶状浸润。她被送往另一家医院，在那里发现她缺氧。动脉血气分析（伴患者呼吸室内空气）pH值为7.42；PCO2, 36 mm Hg；此时她每小时咳出四分之一杯鲜红色的血。尿分析：蛋白尿3 +，镜下血尿，多粒红细胞投模/高倍视野。BUN为38 mg / dl，血清肌酐为2.5 mg / dl。三个月前（择期胆囊切除术时）BUN为20 mg/dl；血清肌酐：1.5 mg/dl；红细胞压积，31%。患者接受红霉素、氧气和输血治疗，并被临时诊断为Goodpasture综合征转至大学医院。仔细询问后发现患者有额部头痛和鼻塞症状约一年。有一次，她因左眼疼痛和“结膜炎”接受了局部抗生素治疗。她还经历了几个月的间歇性关节痛和肘部、手腕和膝盖僵硬。她没有发烧，胸痛，皮疹，脱发，口腔
A 61-year-old white woman was referred to the University Hospital for management of rapidly progressive glomerulonephritis and pulmonary hemorrhage. One week prior to admission, she developed a cough productive of a small amount of bloody sputum; the cough and hemoptysis became worse over the succeeding week. Chest x-ray showed bilateral pulmonary infiltrates in a "butterfly" pattern. She was admitted to another hospital, where she was found to be hypoxic. Arterial blood gas analysis (with the patient breathing room air) showed pH, 7.42; PCO2, 36 mm Hg; and P02, 58 mm Hg. At this time she was coughing up about one-quarter cup of bright red blood per hour. Urinalysis showed 3 + proteinuria, microscopic hematuria, and many granular and red blood cell casts/high-power field. The BUN and serum creatinine were 38 and 2.5 mgldl respectively. Three months earlier (at the time of an elective cholecystectomy) the BUN had been 20 mg/dl; serum creatinine, 1.5 mg/dl; and hematocrit, 31%. The patient was treated with erythromycin, oxygen, and blood transfusion, and was transferred to the University Hospital with the provisional diagnosis of Goodpasture 's syndrome. Careful questioning disclosed that the patient had experienced frontal headaches and nasal congestion for approximately one year. On one occasion, she had been treated with topical antibiotics for pain and "conjunctivitis" of the left eye. She also had experienced intermittent arthralgia and stiffness of the elbows, wrists, and knees for several months. She had not experienced fever, chest pain, rash, hair loss, oral
登录
查看更多内容
肾小球和培养的肾小球系膜细胞中血小板激活因子的产生。
DOI：
10.1152/ajprenal.1986.250.6.f1123
发表时间：
1986
期刊：
The American journal of physiology
影响因子：
--
作者：
Schlondorff,D;Goldwasser,P;Neuwirth,R;Satriano,JA;Clay,KL
通讯作者：
Clay,KL
影响因子：
15.9
作者：
HOLDSWORTH, SR;NEALE, TJ;WILSON, CB
通讯作者：
WILSON, CB
影响因子：
15.9
作者：
BOLTON, WK;TUCKER, FL;STURGILL, BC
通讯作者：
STURGILL, BC
狼疮性肾炎伴血栓形成和纤维蛋白溶解异常：ancrod 的作用。
DOI：
--
发表时间：
1985
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Kant,KS;Pollak,VE;Dosekun,A;Glas-Greenwalt,P;Weiss,MA;Glueck,HI
通讯作者：
Glueck,HI
DOI：
10.1073/pnas.82.24.8667
发表时间：
1985-12-01
影响因子：
11.1
作者：
GAMBLE, JR;HARLAN, JM;VADAS, MA
通讯作者：
VADAS, MA