SARM is required for neuronal injury and cytokine production in response to central nervous system viral infection.
SARM is required for neuronal injury and cytokine production in response to central nervous system viral infection.
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DOI：
10.4049/jimmunol.1300374
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发表时间：
2013-07-15
期刊：
影响因子：
--
通讯作者：
Uccellini MB
中科院分区：
文献类型：
--
作者：
Hou YJ;Banerjee R;Thomas B;Nathan C;García-Sastre A;Ding A;Uccellini MB
Four of the five members of the Toll-interleukin-1 receptor (TIR) domain-containing adaptor family are required for signaling downstream of Toll-like receptors, promoting innate immune responses against different pathogens. However, the role of the fifth member of this family, sterile alpha and TIR-domain containing 1 (SARM), is unclear. SARM is expressed primarily in the central nervous system where it is required for axonal death. Studies in C.elegans have also shown a role for SARM in innate immunity. To clarify the role of mammalian SARM in innate immunity, we infected SARM−/− mice with a number of bacterial and viral pathogens. SARM−/− mice show normal responses to Listeria monocytogenes, Mycobacterium tuberculosis (Mtb), and influenza virus, but show dramatic protection from death after CNS infection with vesicular stomatitis virus (VSV). Protection correlates with reduced CNS injury and cytokine production by non-hematopoietic cells, suggesting that SARM is a positive regulator of cytokine production. Neurons and microglia are the predominant source of cytokines in vivo, supporting a role for SARM as a link between neuronal injury and innate immunity.
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影响因子：
3.7
作者：
Chauhan, Vinita S.;Furr, Samantha R.;Grdzelishvili, Valery Z.
通讯作者：
Grdzelishvili, Valery Z.
影响因子：
14.8
作者：
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通讯作者：
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影响因子：
15.3
作者：
Kim, Younghwa;Zhou, Ping;Ding, Aihao
通讯作者：
Ding, Aihao
DOI：
10.1073/pnas.49.2.187
发表时间：
1963-01-01
影响因子：
11.1
作者：
FRIEDE, RL
通讯作者：
FRIEDE, RL
影响因子：
10.5
作者：
Chuang, CF;Bargmann, CI
通讯作者：
Bargmann, CI