Severity of neonatal opioid withdrawal syndrome with prenatal exposure to serotonin reuptake inhibitors.
Severity of neonatal opioid withdrawal syndrome with prenatal exposure to serotonin reuptake inhibitors.
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DOI：
10.1038/s41390-021-01756-4
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发表时间：
2022-03
影响因子：
3.6
通讯作者：
Salisbury, Amy
中科院分区：
文献类型：
--
作者：
Bakhireva, Ludmila N.;Sparks, Aydan;Herman, Michael;Hund, Lauren;Ashley, Malia;Salisbury, Amy
评估产前暴露于阿片类药物使用障碍（MOUD）和5-羟色胺再摄取抑制剂（SRI）的婴儿中新生儿阿片类药物戒断综合征（NOWS）的严重程度。前瞻性队列包括148对母婴，分为MOUD组（n = 127）和MOUD + SRI组（n = 27）。NOWS严重程度可操作为婴儿是否需要阿片类药物治疗、住院时间和治疗时间。产前SRI暴露与药物治疗需求（logistic回归）、出院时间和停药时间（考克斯比例风险模型）之间的关系在调整了母亲MOUD类型、羟嗪、其他阿片类药物、苯二氮卓类药物/镇静剂、酒精、烟草、大麻、胎龄和母乳喂养后进行了研究。与MOUD组相比，MOUD + SRI组的婴儿更有可能接受NOWS药物治疗（OR = 3.58; 95% CI：1.31; 9.76），住院时间更长（中位数：11 vs. 6天; HR = 0.54; 95% CI：0.33; 0.89）。关于至停止治疗的时间，在接受治疗的婴儿中未观察到相关性（HR = 0.59; 95%CI：0.26，1.32）;然而，在整个样本中观察到显着差异（HR = 0.55; 95%CI：0.34，0.89）。MOUD孕妇使用SRI可能与更严重的NOWS相关。
To evaluate the severity of neonatal opioid withdrawal syndrome (NOWS) in infants prenatally exposed to medications for opioid use disorder (MOUD) and serotonin reuptake inhibitors (SRI). A prospective cohort included 148 maternal–infant pairs categorized into MOUD (n = 127) and MOUD + SRI (n = 27) groups. NOWS severity was operationalized as the infant’s need for pharmacologic treatment with opioids, duration of hospitalization, and duration of treatment. The association between prenatal SRI exposure and the need for pharmacologic treatment (logistic regression), time-to-discharge, and time-to-treatment discontinuation (Cox proportional hazards modeling) was examined after adjusting for the type of maternal MOUD, use of hydroxyzine, other opioids, benzodiazepines/sedatives, alcohol, tobacco, marijuana, gestational age, and breastfeeding. Infants in the MOUD + SRI group were more likely to receive pharmacologic treatment for NOWS (OR = 3.58; 95% CI: 1.31; 9.76) and had a longer hospitalization (median: 11 vs. 6 days; HR = 0.54; 95% CI: 0.33; 0.89) compared to the MOUD group. With respect to time-to-treatment discontinuation, no association was observed in infants who received treatment (HR = 0.59; 95% CI: 0.26, 1.32); however, significant differences were observed in the entire sample (HR = 0.55; 95% CI: 0.34, 0.89). Use of SRIs among pregnant women on MOUD might be associated with more severe NOWS.
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影响因子：
4.2
作者：
Kaltenbach K;O'Grady KE;Heil SH;Salisbury AL;Coyle MG;Fischer G;Martin PR;Stine S;Jones HE
通讯作者：
Jones HE
影响因子：
9.8
作者：
Ananth CV;Schisterman EF
通讯作者：
Schisterman EF
影响因子：
2.6
作者：
Jansson LM;Patrick SW
通讯作者：
Patrick SW
DOI：
10.15288/jsa.1975.36.1154
发表时间：
1975-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
BOWMAN, RS;STEIN, LI;NEWTON, JR
通讯作者：
NEWTON, JR
DOI：
10.1016/j.ogc.2014.02.004
发表时间：
2014-06-01
影响因子：
3.2
作者：
Gopman, Sarah
通讯作者：
Gopman, Sarah