Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.
Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.
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新颖的 P3 降低抑郁症:使用电流源密度 (CSD) 波形的主成分分析 (PCA) 进行表征。
DOI:
10.1111/j.1469-8986.2009.00880.x
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发表时间:
2010
期刊:
影响因子:
3.7
通讯作者:
Bruder,GerardE
中科院分区:
文献类型:
--
作者:
Tenke,CraigE;Kayser,Jürgen;Stewart,JonathanW;Bruder,GerardE
We previously reported a novelty P3 reduction in depressed patients compared to healthy controls (n=20 per group) in a novelty oddball task using a 31‐channel montage. In an independent replication and extension using a 67‐channel montage (n=49 per group), reference‐free current source density (CSD) waveforms were simplified and quantified by a temporal, covariance‐based principal components analysis (PCA) (unrestricted Varimax rotation), yielding factor solutions consistent with other oddball tasks. A factor with a loadings peak at 343 ms summarized the target P3b source as well as a secondary midline frontocentral source for novels and targets. An earlier novelty vertex source (NVS) at 241 ms was present for novels, but not targets, and was reduced in patients. Compatible CSD‐PCA findings were also confirmed for the original low‐density sample. Results are consistent with a reduced novelty response in clinical depression, involving the early phase of the frontocentral novelty P3.
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DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
S. Hillyard
通讯作者:
S. Hillyard
DOI:
--
发表时间:
1985
期刊:
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
影响因子:
--
作者:
F. Omura
通讯作者:
F. Omura
DOI:
--
发表时间:
1988
期刊:
影响因子:
--
作者:
W. Dixon
通讯作者:
W. Dixon
DOI:
10.1016/s0013-4694(97)00119-3
发表时间:
1998-02-01
期刊:
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子:
--
作者:
Halgren, E;Marinkovic, K;Chauvel, P
通讯作者:
Chauvel, P
DOI:
10.1016/0926-6410(94)90020-5
发表时间:
1994-07-01
期刊:
COGNITIVE BRAIN RESEARCH
影响因子:
--
作者:
FRIEDMAN, D;SIMPSON, GV
通讯作者:
SIMPSON, GV