Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.

Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.
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新颖的 P3 降低抑郁症:使用电流源密度 (CSD) 波形的主成分分析 (PCA) 进行表征。

DOI:
10.1111/j.1469-8986.2009.00880.x
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发表时间:
2010
期刊:
影响因子:
3.7
通讯作者:
Bruder,GerardE
Bruder,GerardE
中科院分区:
心理学3区
文献类型:
--
作者:
Tenke,CraigE;Kayser,Jürgen;Stewart,JonathanW;Bruder,GerardE

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我们之前报道了在使用31通道蒙太奇的新奇古怪任务中,与健康对照组(每组n=20)相比,抑郁症患者的新奇P3降低。在使用67通道导联(每组n=49)的独立复制和扩展中,通过基于时间协方差的主成分分析(PCA)(无限制方差最大旋转)简化和量化无参考电流源密度(CSD)波形,产生与其他古怪任务一致的因子解决方案。在343 ms处具有负载峰值的因子概括了目标P3 b源以及小说和目标的次级中线额中央源。在241 ms时,对于小说存在较早的新奇顶点源(NVS),但不存在目标,并且在患者中减少。原始低密度样本的兼容CSD-PCA结果也得到了证实。结果是一致的,减少新颖性反应,在临床抑郁症,涉及早期阶段的额中央新奇P3。
We previously reported a novelty P3 reduction in depressed patients compared to healthy controls (n=20 per group) in a novelty oddball task using a 31‐channel montage. In an independent replication and extension using a 67‐channel montage (n=49 per group), reference‐free current source density (CSD) waveforms were simplified and quantified by a temporal, covariance‐based principal components analysis (PCA) (unrestricted Varimax rotation), yielding factor solutions consistent with other oddball tasks. A factor with a loadings peak at 343 ms summarized the target P3b source as well as a secondary midline frontocentral source for novels and targets. An earlier novelty vertex source (NVS) at 241 ms was present for novels, but not targets, and was reduced in patients. Compatible CSD‐PCA findings were also confirmed for the original low‐density sample. Results are consistent with a reduced novelty response in clinical depression, involving the early phase of the frontocentral novelty P3.
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影响因子: --
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