The biology of APOL1 with insights into the association between APOL1 variants and chronic kidney disease.

The biology of APOL1 with insights into the association between APOL1 variants and chronic kidney disease.
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DOI:
10.1007/s10157-013-0907-4
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发表时间:
2014-04
影响因子:
2.3
通讯作者:
O'Toole, John F.
O'Toole, John F.
中科院分区:
医学4区
文献类型:
--
作者:
Madhavan, Sethu M.;O'Toole, John F.

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最近的研究已经确定了APOL1的遗传变异可能导致非洲血统人群中肾脏疾病的发病率增加。在此,我们回顾了存在于循环和定位于肾脏的APOL1的生物学,因为它可能有助于APOL1相关肾脏疾病的发病机制。
Recent studies have identified genetic variants in APOL1 that may contribute to the increased incidence of kidney disease in populations with African ancestry. Herein, we review the biology of APOL1 present in the circulation and localized to the kidney as it may contribute to the pathogenesis of APOL1 associated kidney disease.
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