Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression.
Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression.
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全氟烷基和多氟烷基物质暴露与高脂肪饮食相结合可促进前列腺癌的进展。
DOI：
10.3390/nu13113902
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发表时间：
2021-10-30
期刊：
影响因子：
5.9
通讯作者：
Madak Erdogan Z
中科院分区：
文献类型：
--
作者：
Imir OB;Kaminsky AZ;Zuo QY;Liu YJ;Singh R;Spinella MJ;Irudayaraj J;Hu WY;Prins GS;Madak Erdogan Z
全氟烷基和多氟烷基物质（PFAS）是用于各种工业环境的合成化学品，包括阻燃剂、人造成膜泡沫、化妆品和不粘炊具等产品。流行病学研究表明，血液中PFAS水平升高与前列腺癌发病率之间存在联系，但PFAS影响癌症发展的机制尚不清楚。为了研究PFAS和前列腺癌之间的联系，我们评估了高脂饮食结合PFAS暴露导致的代谢改变对前列腺肿瘤进展的影响。我们评估了暴露于全氟辛烷磺酸（PFOS）（一种PFAS化合物）和不同饮食的体内前列腺癌异种移植模型，以研究PFAS对前列腺癌进展和代谢活性的影响。代谢组学和转录组学被用来了解PFAS暴露后的代谢景观变化。我们评估了良性或肿瘤细胞中的代谢变化，这些变化导致表观基因组重编程和改变的信号传导，最终增加了肿瘤发生的风险和肿瘤的侵袭性。我们的研究是该领域第一个提供新的和临床相关的见解，关于新的代谢和表观遗传状态，以及支持PFAS诱导的前列腺癌的有效预防和治疗策略的未来发展。我们的研究结果增强了对PFAS如何与高脂肪饮食协同作用促进前列腺癌发展的理解，并为减轻PFAS暴露奠定了重要基础。
Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals utilized in various industrial settings and include products such as flame retardants, artificial film-forming foams, cosmetics, and non-stick cookware, among others. Epidemiological studies suggest a link between increased blood PFAS levels and prostate cancer incidence, but the mechanism through which PFAS impact cancer development is unclear. To investigate the link between PFAS and prostate cancer, we evaluated the impact of metabolic alterations resulting from a high-fat diet combined with PFAS exposure on prostate tumor progression. We evaluated in vivo prostate cancer xenograft models exposed to perfluorooctane sulfonate (PFOS), a type of PFAS compound, and different diets to study the effects of PFAS on prostate cancer progression and metabolic activity. Metabolomics and transcriptomics were used to understand the metabolic landscape shifts upon PFAS exposure. We evaluated metabolic changes in benign or tumor cells that lead to epigenomic reprogramming and altered signaling, which ultimately increase tumorigenic risk and tumor aggressiveness. Our studies are the first in the field to provide new and clinically relevant insights regarding novel metabolic and epigenetic states as well as to support the future development of effective preventative and therapeutic strategies for PFAS-induced prostate cancers. Our findings enhance understanding of how PFAS synergize with high-fat diets to contribute to prostate cancer development and establish an important basis to mitigate PFAS exposure.
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影响因子：
37.3
作者：
Costello, Leslie C;Franklin, Renty B
通讯作者：
Franklin, Renty B
影响因子：
5.2
作者：
Cotul EK;Zuo Q;Santaliz-Casiano A;Imir OB;Mogol AN;Tunc E;Duong K;Lee JK;Ramesh R;Odukoya E;Kesavadas MP;Ziogaite M;Smith BP;Mao C;Shapiro DJ;Park BH;Katzenellenbogen BS;Daly D;Aranda E;O'Neill JD;Walker C;Landesman Y;Madak-Erdogan Z
通讯作者：
Madak-Erdogan Z
DOI：
10.1016/j.mrgentox.2010.04.024
发表时间：
2010-07-19
影响因子：
1.9
作者：
Eriksen, Kirsten Thorup;Raaschou-Nielsen, Ole;Moller, Peter
通讯作者：
Moller, Peter
影响因子：
3.2
作者：
Fernandez Freire, P.;Martin, J. M. Perez;Hazen, M. J.
通讯作者：
Hazen, M. J.
影响因子：
11.8
作者：
Legoff, Louis;D'Cruz, Shereen Cynthia;Smagulova, Fatima
通讯作者：
Smagulova, Fatima