Age-related decline in cognitive flexibility is associated with the levels of hippocampal neurogenesis.
Age-related decline in cognitive flexibility is associated with the levels of hippocampal neurogenesis.
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DOI：
10.3389/fnins.2023.1232670
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发表时间：
2023
影响因子：
4.3
通讯作者：
Enikolopov, Grigori
中科院分区：
文献类型：
--
作者：
Amelchenko, Evgeny M.;Bezriadnov, Dmitri V.;Chekhov, Olga A.;Anokhin, Konstantin V.;Lazutkin, Alexander A.;Enikolopov, Grigori
关键词：
衰老与学习、记忆和认知灵活性的损伤以及海马神经发生的逐渐下降有关。我们研究了6个月和14个月大的小鼠（分别被认为是成年和中年晚期）在基于Morris水迷宫（MWM）的学习和记忆任务中的表现，并测定了它们之前和现在的神经发生水平。虽然两个年龄组都成功地完成了空间版本的MWM (sMWM)，但当提出修改版本的MWM（需要重新评估先前获得的经验）时，老年小鼠的效率低于年轻小鼠。这在反向MWM （rMWM）中被发现，在上下文辨别MWM （cdMWM）中尤为明显，这是一项需要整合各种远端线索、局部线索和改变的上下文并调整先前使用的搜索策略的新任务。老年小鼠在rMWM和cdMWM的几个指标上受损，然而，经过额外的训练，它们表现出改善，缩小了与年轻小鼠的表现差距。此外，我们分析了海马齿状回中成年出生的成熟和未成熟神经元，发现个体小鼠的神经发生水平与其在需要认知灵活性的任务中的表现之间存在显著相关性。这些结果详细描述了与年龄相关的学习和记忆变化，并强调了海马神经发生在支持认知灵活性方面的重要性。
Aging is associated with impairments in learning, memory, and cognitive flexibility, as well as a gradual decline in hippocampal neurogenesis. We investigated the performance of 6-and 14-month-old mice (considered mature adult and late middle age, respectively) in learning and memory tasks based on the Morris water maze (MWM) and determined their levels of preceding and current neurogenesis. While both age groups successfully performed in the spatial version of MWM (sMWM), the older mice were less efficient compared to the younger mice when presented with modified versions of the MWM that required a reassessment of the previously acquired experience. This was detected in the reversal version of MWM (rMWM) and was particularly evident in the context discrimination MWM (cdMWM), a novel task that required integrating various distal cues, local cues, and altered contexts and adjusting previously used search strategies. Older mice were impaired in several metrics that characterize rMWM and cdMWM, however, they showed improvement and narrowed the performance gap with the younger mice after additional training. Furthermore, we analyzed the adult-born mature and immature neurons in the hippocampal dentate gyrus and found a significant correlation between neurogenesis levels in individual mice and their performance in the tasks demanding cognitive flexibility. These results provide a detailed description of the age-related changes in learning and memory and underscore the importance of hippocampal neurogenesis in supporting cognitive flexibility.
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影响因子：
4.8
作者：
Koehl M;Ladevèze E;Montcouquiol M;Abrous DN
通讯作者：
Abrous DN
影响因子：
3.3
作者：
Driscoll, I.;Howard, S. R.;Sutherland, R. J.
通讯作者：
Sutherland, R. J.
影响因子：
16.6
作者：
Berdugo-Vega, Gabriel;Arias-Gil, Gonzalo;Calegari, Federico
通讯作者：
Calegari, Federico
DOI：
10.1073/pnas.0601992103
发表时间：
2006-05-23
影响因子：
11.1
作者：
Encinas, Juan M.;Vaahtokari, Anne;Enikolopov, Grigori
通讯作者：
Enikolopov, Grigori
影响因子：
5.3
作者：
Arruda-Carvalho, Maithe;Sakaguchi, Masanori;Frankland, Paul W.
通讯作者：
Frankland, Paul W.