Change in blood pressure variability in patients with acute ischemic stroke and its effect on early neurologic outcome.
Change in blood pressure variability in patients with acute ischemic stroke and its effect on early neurologic outcome.
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DOI：
10.1371/journal.pone.0189216
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Bae HJ
中科院分区：
文献类型：
--
作者：
Kang J;Hong JH;Jang MU;Choi NC;Lee JS;Kim BJ;Han MK;Bae HJ
短期血压变异性 (BPV) 在缺血性卒中急性期如何受到影响以及 BPV 是否与早期神经系统结局相关仍不清楚。 2010 年 1 月至 2015 年 1 月期间，连续识别出症状出现 24 小时内因缺血性中风入院的患者。根据前 3 天内的标准差 (SD) 和收缩压平均值 (SBPSD)，将实时测量的血压曲线总结为短期、24 小时时间间隔。主要结局是每日评估早期神经功能恶化（END）。研究了短期 SBPSD 值与主要结局的长期趋势之间的关联。共有 2,545 名受试者（平均年龄为 67.1 ± 13.5 岁，美国国立卫生研究院卒中量表基线评分中位数为 3），平均在症状出现后 6.1 ± 6.6 小时到达医院。第 1 天 (SD#D1)、SD#D2 和 SD#D3 的 SBPSD 值分别为 14.4 ± 5.0、12.5 ± 4.5 和 12.2 ± 4.6 mmHg。多变量分析显示，SD#D2 与第 2 天 END 的发生独立相关（调整后的比值比，1.08；95% 置信区间，1.03–1.13），SD#D3 与 END#D3 独立相关（1.07、1.01–1.14），并对预定协变量、SBPmean 以及与每日 SBPSD 的交互作用进行了调整。从缺血性中风的第一天起，短期BPV发生变化并趋于稳定。每日高 BPV 可能与神经功能恶化有关，与前一天的 BPV 无关。
How short-term blood pressure variability (BPV) is affected in the acute stage of ischemic stroke and whether BPV is associated with early neurologic outcomes remains unclear. Patients who admitted for ischemic stroke within 24 h of symptom onset were consecutively identified between January 2010 and January 2015. BP profiles measured in real-time were summarized into short-term, 24-h time intervals, based on standard deviation (SD) and mean of systolic BP (SBPSD) during the first 3 days. The primary outcome was daily assessment of early neurological deterioration (END). The associations between short-term SBPSD values and the secular trend for primary outcome were examined. A total of 2,545 subjects (mean age, 67.1 ± 13.5 years old and median baseline National Institutes of Health Stroke Scale score, 3) arrived at the hospital an average of 6.1 ± 6.6 h after symptom onset. SBPSD values at day 1 (SD#D1), SD#D2, and SD#D3 were 14.4 ± 5.0, 12.5 ± 4.5, and 12.2 ± 4.6 mmHg, respectively. Multivariable analyses showed that SD#D2 was independently associated with onset of END at day 2 (adjusted odds ratio, 1.08; 95% confidence interval, 1.03–1.13), and SD#D3 was independently associated with END#D3 (1.07, 1.01–1.14), with adjustments for predetermined covariates, SBPmean, and interactions with daily SBPSD. Short-term BPV changed and stabilized from the first day of ischemic stroke. Daily high BPV may be associated with neurological deterioration independent of BPV on the previous day.
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DOI：
10.1161/hypertensionaha.112.202143
发表时间：
2012-11
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Schutte R;Thijs L;Liu YP;Asayama K;Jin Y;Odili A;Gu YM;Kuznetsova T;Jacobs L;Staessen JA
通讯作者：
Staessen JA
影响因子：
8.3
作者：
Jauch, Edward C.;Saver, Jeffrey L.;Yonas, Howard
通讯作者：
Yonas, Howard
影响因子：
8.3
作者：
Endo, Kaoru;Kario, Kazuomi;Toyoda, Kazunori
通讯作者：
Toyoda, Kazunori
影响因子：
8.3
作者：
Manning, Lisa S.;Mistri, Amit K.;Robinson, Thompson G.
通讯作者：
Robinson, Thompson G.
影响因子：
8.8
作者：
Cuthbertson, Brian H.;Boroujerdi, Massoud;Prescott, Gordon
通讯作者：
Prescott, Gordon