Beyond social withdrawal: New perspectives on the effects of inflammation on social behavior.
Beyond social withdrawal: New perspectives on the effects of inflammation on social behavior.
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DOI：
10.1016/j.bbih.2021.100302
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Inagaki TK
中科院分区：
文献类型：
--
作者：
Muscatell KA;Inagaki TK
数十年来对动物和人类的研究表明，炎症是社会行为的重要调节器。虽然这一领域的许多研究都得出结论，炎症会导致退出社会交往，但对文献的仔细研究表明，炎症对社会行为的影响要微妙得多。事实上，虽然许多研究确实表明炎症的增加会导致社交退缩，但其他研究表明恰恰相反，发现炎症会导致社交行为的增加。重要的是，一个有机体在发炎时是退缩还是接近可能取决于行为的目标是亲密的人还是陌生人。在本文中，我们回顾了动物研究和我们在人类中的初步研究，这些研究利用了炎症的实验操作，并研究了它们对社会接近行为的影响。我们认为，基于互补的理论观点和文献中的支持证据，翻译工作有三个关键的下一步检查炎症对社会行为的影响：（1）我们需要研究实际的社会行为，如对亲密他人和陌生人的表达;（2）我们不仅应该检查发炎个体的社会行为，还应该检查与发炎个体互动的其他人的行为;和（3）我们必须考虑炎症的相对增加（即，较高与较低）作为社交退缩与接近的贡献者。最终，我们敦促该领域超越对炎症和社会退缩的单一关注，以便我们能够更全面地了解炎症对各种社会行为的影响。
Decades of research in animals and humans show that inflammation is an important regulator of social behavior. While much research in this area has concluded that inflammation causes a withdrawal from social interaction, closer examination of the literature reveals that the effects of inflammation on social behavior are much more nuanced. Indeed, while many studies do show that increases in inflammation lead to social withdrawal, other studies show the exact opposite, finding that inflammation leads to an increase in social approach behavior. Critically, whether an organism withdraws or approaches when inflamed may depend on the whether the target of the behavior is a close other or a stranger. In the present paper, we review both animal research and our initial research in humans that has utilized experimental manipulations of inflammation and examined their effects on social approach behavior. We argue, based on complementary theoretical perspectives and supporting evidence from the literature, that there are three critical next steps for translational work examining the effects of inflammation on social behavior: (1) We need to study actual social behavior, as expressed toward both close others and strangers; (2) We should examine not just the social behavior of the inflamed individual, but also the behavior of others interacting with an inflamed individual; and (3) We must consider the relative increases in inflammation (i.e., higher vs. lower) as a contributor to social withdrawal vs. approach. Ultimately, we urge the field to move beyond a singular focus on inflammation and social withdrawal so that we can develop a more comprehensive understanding of the effects of inflammation on a variety of social behaviors.
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影响因子：
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