Taking the guesswork out of uveal melanoma.
Taking the guesswork out of uveal melanoma.
复制标题
消除葡萄膜黑色素瘤的猜测。
DOI:
10.1056/nejme1010681
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发表时间:
2010
期刊:
影响因子:
--
通讯作者:
Nathanson,KatherineL
中科院分区:
文献类型:
--
作者:
Herlyn,Meenhard;Nathanson,KatherineL
Therapy for melanoma is making remarkable progress. Only 8 years after the initial discovery of mutations in theBRAFoncogene, a new small-molecule inhibitor specific for mutant BRAF, PLX4032 (also known as RG7204), induced tumor shrinkage in more than 80% of patients with cutaneous melanoma containingBRAFmutations and extended progression-free survival by an average of 7 months.1,2Although BRAF-targeted therapy is not curative, it is possible that its combination with immunotherapy to potentiate antitumor T-cell responses may lead to durable responses.3The mutant BRAF amino acid that is targeted by PLX4032 is present in 50% of cutaneous melanomas . . .
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影响因子:
3.4
作者:
T. Lentz;J. Chester;Robin J. J. Benson;E. Hawrot;G. H. Tignor;Abigail L. Smith
通讯作者:
Abigail L. Smith
影响因子:
56.9
作者:
LENTZ, TL;BURRAGE, TG;TIGNOR, GH
通讯作者:
TIGNOR, GH
影响因子:
4.7
作者:
J. Schmidt;M. Raftery
通讯作者:
M. Raftery
DOI:
10.1099/0022-1317-67-1-47
发表时间:
1986
期刊:
The Journal of general virology
影响因子:
--
作者:
F. Superti;B. Hauttecoeur;M. Morelec;P. Goldoni;B. Bizzini;H. Tsiang
通讯作者:
H. Tsiang
DOI:
10.1073/pnas.80.16.4973
发表时间:
1983
影响因子:
11.1
作者:
Gershoni,JM;Hawrot,E;Lentz,TL
通讯作者:
Lentz,TL