Taking the guesswork out of uveal melanoma.

Taking the guesswork out of uveal melanoma.
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消除葡萄膜黑色素瘤的猜测。

DOI:
10.1056/nejme1010681
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发表时间:
2010
期刊:
The New England journal of medicine
影响因子:
--
通讯作者:
Nathanson,KatherineL
Nathanson,KatherineL
中科院分区:
--
文献类型:
--
作者:
Herlyn,Meenhard;Nathanson,KatherineL

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Therapy for melanoma is making remarkable progress. Only 8 years after the initial discovery of mutations in theBRAFoncogene, a new small-molecule inhibitor specific for mutant BRAF, PLX4032 (also known as RG7204), induced tumor shrinkage in more than 80% of patients with cutaneous melanoma containingBRAFmutations and extended progression-free survival by an average of 7 months.1,2Although BRAF-targeted therapy is not curative, it is possible that its combination with immunotherapy to potentiate antitumor T-cell responses may lead to durable responses.3The mutant BRAF amino acid that is targeted by PLX4032 is present in 50% of cutaneous melanomas . . .
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