Molecular and clinicopathological differences between depressed and protruded T2 colorectal cancer.
Molecular and clinicopathological differences between depressed and protruded T2 colorectal cancer.
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DOI：
10.1371/journal.pone.0273566
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
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作者：
根据基因组畸变率和基因表达谱，结直肠癌可分为四种常见的分子亚型。CMS有望在预测预后和选择化疗方案中发挥重要作用。然而，有关形态与细胞质雄性不育之间关系的报道还未见报道。这项回顾性研究包括55例接受手术切除的T2结直肠癌患者，其中30例为凹陷型，25例为隆起型。在CMS的分类中，我们首先将错配修复缺失的病例定义为CMS1。然后，使用Trin等人开发的在线分类器对CMS2/3和CMS4进行分类。将CDX2、HTR2B、FRMD6、ZEB1和Ker的染色强度以及CDX2、FRMD6和Ker的百分比含量输入分类器，即可自动输出将标本分类为CMS2/3或CMS4。根据在线分类器的结果，在30例抑郁型病例中，15例(50%)被归类为CMS2/3，15例(50%)被归类为CMS4。在25例隆起型病例中，CMS1型3例(12%)，CMS2/3型22例(88%)。更多的恶性病理表现，如淋巴侵犯，与凹陷型而不是隆起型T2结直肠癌有关。凹陷型T2结直肠癌与CMS4有显著的相关性，表现出比隆起型更多的恶性病理表现，如淋巴侵犯，这可以解释已报道的CMS4型结直肠癌与预后不良的关联。
Colorectal cancer (CRC) can be classified into four consensus molecular subtypes (CMS) according to genomic aberrations and gene expression profiles. CMS is expected to be useful in predicting prognosis and selecting chemotherapy regimens. However, there are still no reports on the relationship between the morphology and CMS. This retrospective study included 55 subjects with T2 CRC undergoing surgical resection, of whom 30 had the depressed type and 25 the protruded type. In the classification of the CMS, we first defined cases with deficient mismatch repair as CMS1. And then, CMS2/3 and CMS4 were classified using an online classifier developed by Trinh et al. The staining intensity of CDX2, HTR2B, FRMD6, ZEB1, and KER and the percentage contents of CDX2, FRMD6, and KER are input into the classifier to obtain automatic output classifying the specimen as CMS2/3 or CMS4. According to the results yielded by the online classifier, of the 30 depressed-type cases, 15 (50%) were classified as CMS2/3 and 15 (50%) as CMS4. Of the 25 protruded-type cases, 3 (12%) were classified as CMS1 and 22 (88%) as CMS2/3. All of the T2 CRCs classified as CMS4 were depressed CRCs. More malignant pathological findings such as lymphatic invasion were associated with the depressed rather than protruded T2 CRC cases. Depressed-type T2 CRC had a significant association with CMS4, showing more malignant pathological findings such as lymphatic invasion than the protruded-type, which could explain the reported association between CMS4 CRC and poor prognosis.
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DOI：
10.1158/1078-0432.ccr-09-0401
发表时间：
2009-07-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Baba Y;Nosho K;Shima K;Freed E;Irahara N;Philips J;Meyerhardt JA;Hornick JL;Shivdasani RA;Fuchs CS;Ogino S
通讯作者：
Ogino S
影响因子：
11.5
作者：
Sveen, Anita;Bruun, Jarle;Lothe, Ragnhild A.
通讯作者：
Lothe, Ragnhild A.
影响因子：
29.4
作者：
Hiraoka, Sakiko;Kato, Jun;Shiratori, Yasushi
通讯作者：
Shiratori, Yasushi
影响因子：
3.7
作者：
Kim HJ;Choi WJ;Lee CH
通讯作者：
Lee CH
影响因子：
--
作者：
Okita A;Takahashi S;Ouchi K;Inoue M;Watanabe M;Endo M;Honda H;Yamada Y;Ishioka C
通讯作者：
Ishioka C