Cutting edge: Natural helper cells derive from lymphoid progenitors.
Cutting edge: Natural helper cells derive from lymphoid progenitors.
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DOI：
10.4049/jimmunol.1102039
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发表时间：
2011-12-01
期刊：
影响因子：
--
通讯作者：
Bhandoola A
中科院分区：
文献类型：
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作者：
Yang Q;Saenz SA;Zlotoff DA;Artis D;Bhandoola A
Natural Helper (NH) cells are recently discovered innate immune cells that confer protective type 2 immunity during helminth infection and mediate influenza induced airway hypersensitivity. Little is known about the ontogeny of NH cells. We now report NH cells derive from bone marrow lymphoid progenitors. Using RAG-1Cre/ROSA26YFP mice, we show that the majority of NH cells are marked with a history of RAG-1 expression, implying lymphoid developmental origin. The development of NH cells depends on the cytokine receptor Flt3, which is required for the efficient generation of bone marrow lymphoid progenitors. Finally, we demonstrate that lymphoid progenitors, but not myeloid-erythroid progenitors, give rise to NH cells in vivo. This work therefore expands the lymphocyte family, currently comprising T, B and NK cells, to include NH cells as another type of innate lymphocyte that derives from bone marrow lymphoid progenitors.
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DOI：
10.4049/jimmunol.0902333
发表时间：
2009-12-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Welner RS;Esplin BL;Garrett KP;Pelayo R;Luche H;Fehling HJ;Kincade PW
通讯作者：
Kincade PW
影响因子：
20.3
作者：
Perry, SS;Wang, HF;Spangrude, GJ
通讯作者：
Spangrude, GJ
DOI：
10.1073/pnas.1003988107
发表时间：
2010-06-22
影响因子：
11.1
作者：
Price, April E.;Liang, Hong-Erh;Locksley, Richard M.
通讯作者：
Locksley, Richard M.
影响因子：
32.4
作者：
Igarashi, H;Gregory, SC;Kincade, PW
通讯作者：
Kincade, PW
影响因子：
64.8
作者：
通讯作者：
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