Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
复制标题
作者：
先天免疫提供了抵抗入侵病原体的第一道防线，并为适应性免疫的发展提供了重要线索。2型免疫-负责对蠕虫寄生虫的保护性免疫应答和过敏性哮喘发病机制的根本原因-由主要2型细胞因子白细胞介素（IL）-4，IL-5和IL-13主导的应答组成（参考文献）。T细胞是获得性免疫应答中这些细胞因子的重要来源，但先天性细胞来源仍有待全面阐明。在这里，通过使用新的Il 13 eGFP报告小鼠，我们提出了一个新的先天2型免疫效应白细胞，我们命名为nuocyte的识别和功能特性。核细胞在体内扩增响应2型诱导细胞因子IL-25和IL-33，并代表蠕虫感染巴西日本圆线虫期间IL-13的主要早期来源。在IL-25和IL-33信号传导的组合缺乏下，核细胞不能扩增，导致蠕虫排出的严重缺陷，其通过体外培养的野生型而不是IL-13缺陷型核细胞的过继转移来挽救。因此，核细胞代表2型免疫中至关重要的先天效应细胞。
Innate immunity provides the first line of defence against invading pathogens and provides important cues for the development of adaptive immunity. Type-2 immunity – responsible for protective immune responses to helminth parasites and the underlying cause of the pathogenesis of allergic asthma – consists of responses dominated by the cardinal type-2 cytokines interleukin (IL)-4, IL-5 and IL-13 (ref.). T cells are an important source of these cytokines in adaptive immune responses, but the innate cell sources remain to be comprehensively elucidated. Here, through the use of novel Il13eGFP reporter mice, we present the identification and functional characterisation of a new innate type-2 immune effector leukocyte that we have named the nuocyte. Nuocytes expand in vivo in response to the type 2-inducing cytokines IL-25 and IL-33, and represent the predominant early source of IL-13 during helminth infection with Nippostrongylus brasiliensis. In the combined absence of IL-25 and IL-33 signalling, nuocytes fail to expand, resulting in a severe defect in worm expulsion that is rescued by the adoptive transfer of in vitro cultured wildtype, but not IL-13-deficient, nuocytes. Thus, nuocytes represent a critically important innate effector cell in type-2 immunity.
登录
查看更多内容
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
14.9
作者：
Warming S;Costantino N;Court DL;Jenkins NA;Copeland NG
通讯作者：
Copeland NG
影响因子：
32.4
作者：
Urban, JF;Noben-Trauth, N;Finkelman, FD
通讯作者：
Finkelman, FD
DOI：
10.1084/jem.20091903
发表时间：
2009-09-28
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Maizels RM;Pearce EJ;Artis D;Yazdanbakhsh M;Wynn TA
通讯作者：
Wynn TA
DOI：
10.1084/jem.189.10.1565
发表时间：
1999-05-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
McKenzie GJ;Fallon PG;Emson CL;Grencis RK;McKenzie AN
通讯作者：
McKenzie AN