The Pivotal Player: Components of NF-κB Pathway as Promising Biomarkers in Colorectal Cancer.
The Pivotal Player: Components of NF-κB Pathway as Promising Biomarkers in Colorectal Cancer.
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DOI：
10.3390/ijms22147429
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发表时间：
2021-07-11
影响因子：
5.6
通讯作者：
Lu T
中科院分区：
文献类型：
--
作者：
Martin M;Sun M;Motolani A;Lu T
在过去的几十年里，结直肠癌（CRC）一直是最常见的癌症之一。虽然在诊断筛查和治疗方法方面都取得了重大进展，但关于CRC的早期识别和治疗仍然存在很大的知识差距。具体而言，鉴定CRC生物标志物可以帮助创建靶向治疗以及提高临床医生预测患者对治疗剂的生物反应的能力，这一点特别重要。本文综述了CRC及其进展阶段，以及CRC生物标志物的基本类型。然后，我们列出了与CRC相关的信号通路的概要，并进一步强调了核因子（NF）κB信号在CRC中的关键和多方面的作用。特别是，我们带来了关于CRC中肿瘤微环境（TME）及其与癌细胞复杂相互作用的知识。我们还提供了NF-κB信号相关的CRC生物标志物的例子，以及在CRC治疗中靶向NF-κB信号的持续努力。我们的结论和预期是，随着越来越多的NF-κB通路新调控因子的发现，以及它们的深入表征和大量基因组学、转录组学和蛋白质组学数据的整合，成功开发更理想的NF-κB抑制剂的日子正在迅速临近。
Over the last several decades, colorectal cancer (CRC) has been one of the most prevalent cancers. While significant progress has been made in both diagnostic screening and therapeutic approaches, a large knowledge gap still remains regarding the early identification and treatment of CRC. Specifically, identification of CRC biomarkers that can help with the creation of targeted therapies as well as increasing the ability for clinicians to predict the biological response of a patient to therapeutics, is of particular importance. This review provides an overview of CRC and its progression stages, as well as the basic types of CRC biomarkers. We then lay out the synopsis of signaling pathways related to CRC, and further highlight the pivotal and multifaceted role of nuclear factor (NF) κB signaling in CRC. Particularly, we bring forth knowledge regarding the tumor microenvironment (TME) in CRC, and its complex interaction with cancer cells. We also provide examples of NF-κB signaling-related CRC biomarkers, and ongoing efforts made at targeting NF-κB signaling in CRC treatment. We conclude and anticipate that with more emerging novel regulators of the NF-κB pathway being discovered, together with their in-depth characterization and the integration of large groups of genomic, transcriptomic and proteomic data, the day of successful development of more ideal NF-κB inhibitors is fast approaching.
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影响因子：
6.4
作者：
Huynh PT;Beswick EJ;Coronado YA;Johnson P;O'Connell MR;Watts T;Singh P;Qiu S;Morris K;Powell DW;Pinchuk IV
通讯作者：
Pinchuk IV
DOI：
10.3122/jabfm.2016.06.160060
发表时间：
2016-11-12
期刊：
Journal of the American Board of Family Medicine : JABFM
影响因子：
--
作者：
Doubeni CA;Jensen CD;Fedewa SA;Quinn VP;Zauber AG;Schottinger JE;Corley DA;Levin TR
通讯作者：
Levin TR
影响因子：
--
作者：
Campos-da-Paz, Mariana;Dorea, Jose Garrofe;de Fatima Menezes Almeida Santos, Maria
通讯作者：
de Fatima Menezes Almeida Santos, Maria
影响因子：
1.1
作者：
Fan JZ;Wang GF;Cheng XB;Dong ZH;Chen X;Deng YJ;Song X
通讯作者：
Song X
影响因子：
9.2
作者：
Gupta, Subash C.;Kim, Ji Hye;Prasad, Sahdeo;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.