Sustained Inflation Versus Intermittent Positive Pressure Ventilation for Preterm Infants at Birth: Respiratory Function and Vital Sign Measurements.
Sustained Inflation Versus Intermittent Positive Pressure Ventilation for Preterm Infants at Birth: Respiratory Function and Vital Sign Measurements.
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DOI：
10.1016/j.jpeds.2021.08.038
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Te Pas AB
中科院分区：
文献类型：
--
作者：
Foglia EE;Kirpalani H;Ratcliffe SJ;Davis PG;Thio M;Hummler H;Lista G;Cavigioli F;Schmölzer GM;Keszler M;Te Pas AB
目的：描述婴儿肺持续充气(SAIL)试验中持续充气和间歇正压呼吸(IPPV)无创应用的呼吸功能监测(RFM)测量的特征，并比较治疗组和治疗组之间的生命体征测量。我们分析了五个试验点的SAIL参与者的RFM数据。我们评估了分配给SI和IPPV的婴儿的潮气量、呼吸道阻塞率和面罩渗漏，并比较了治疗组之间的脉率和血氧饱和度(SpO2)测量。在进行RFM测量的70名SAIL参与者(36名SI，34名IPPV)中，40名(57%)在随机干预前是自主呼吸。SIS的呼气潮气量(VTE)中位数为5.3mL/kg(IQR1.1~9.2)。15%的患者出现明显的口罩渗漏，17%的患者出现呼吸道阻塞。在34名对照组婴儿中，IPPV充气的中位数VTE为4.3mL/kg(IQR 1.3~6.6)。3%的患者出现面罩渗漏，17%的患者出现呼吸道阻塞。在复苏过程中的任何时间点，两组之间的脉率或SpO2测量没有显著差异。在SAIL试验中，SI和IPPV充气的呼气潮气量在两个治疗组中都有很大的差异。在整个复苏过程中，各组之间的生命体征值是相似的。在本研究亚组中，在SAIL试验中操作的SI在促进出生后肺充气方面并不优于IPPV。ClinicalTrials.gov：NCT02139800
To characterize respiratory function monitor (RFM) measurements of sustained inflations and intermittent positive pressure ventilation (IPPV) delivered non-invasively to infants in the Sustained Aeration of Infant Lungs (SAIL) trial and to compare vital sign measurements between treatment arms. We analyzed RFM data from SAIL participants at five trial sites. We assessed tidal volumes, rates of airway obstruction and mask leak among infants allocated to SI and IPPV, and we compared pulse rate and oxygen saturation (SpO2) measurements between treatment groups. Among 70 SAIL participants (36 SI, 34 IPPV) with RFM measurements, 40 (57%) were spontaneously breathing prior to the randomized intervention. The median expiratory tidal volume (Vte) of SIs administered was 5.3 mL/kg (IQR 1.1–9.2). Significant mask leak occurred in 15% and airway obstruction occurred during 17% of SIs. Among 34 control infants, the median Vte of IPPV inflations was 4.3 mL/kg (IQR 1.3–6.6). Mask leak was present in 3% and airway obstruction was present in 17% IPPV inflations. There were no significant differences in pulse rate or SpO2 measurements between groups at any point during resuscitation. Expiratory tidal volumes of SI and IPPV inflations administered in the SAIL trial were highly variable in both treatment arms. Vital sign values were similar between groups throughout resuscitation. SI as operationalized in the SAIL trial was not superior to IPPV to promote lung aeration after birth in this study subgroup. Clinicaltrials.gov: NCT02139800
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影响因子：
6.5
作者：
Poulton, David A.;Schmoelzer, Georg M.;Davis, Peter G.
通讯作者：
Davis, Peter G.
影响因子：
2.6
作者：
Kirpalani, Haresh;Keszler, Martin;Ratcliffe, Sarah
通讯作者：
Ratcliffe, Sarah
影响因子：
3.6
作者：
te Pas, Arjan B.;Siew, Melissa;Hooper, Stuart B.
通讯作者：
Hooper, Stuart B.
DOI：
10.1136/adc.2010.191171
发表时间：
2011-07-01
影响因子：
4.4
作者：
Schmoelzer, Georg M.;Dawson, Jennifer A.;Davis, Peter G.
通讯作者：
Davis, Peter G.
影响因子：
6.5
作者：
van Zanten, Henriette A.;Kuypers, Kristel L. A. M.;te Pas, Arjan B.
通讯作者：
te Pas, Arjan B.