Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination.
Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination.
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DOI：
10.1172/jci.insight.151463
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发表时间：
2021-11-22
期刊：
影响因子：
8
通讯作者：
Smed-Sörensen A
中科院分区：
文献类型：
--
作者：
Cagigi A;Yu M;Österberg B;Svensson J;Falck-Jones S;Vangeti S;Åhlberg E;Azizmohammadi L;Warnqvist A;Falck-Jones R;Gubisch PC;Ödemis M;Ghafoor F;Eisele M;Lenart K;Bell M;Johansson N;Albert J;Sälde J;Pettie DD;Murphy MP;Carter L;King NP;Ols S;Normark J;Ahlm C;Forsell MN;Färnert A;Loré K;Smed-Sörensen A
了解呼吸道中SARS-CoV-2抗体的存在和持久性，有助于了解个体在局部中和病毒并防止病毒传播的能力。在这里，我们纵向评估了SARS-CoV-2感染后的全身和气道免疫反应，其中147名感染者的临床特征良好，代表了COVID-19严重程度的全谱，从无症状感染到致命疾病。此外，我们评估了SARS-CoV-2疫苗接种如何影响这些个体在恢复期的抗体应答，与未接种过疫苗的个体相比。不仅全身抗体反应，而且呼吸道抗体反应与COVID-19疾病的严重程度相关。然而，尽管全身IgG水平可持续长达8个月，但气道IgG和伊加在3个月内显著下降。接种疫苗后，全身和呼吸道抗体，特别是IgG，增加，往往超过急性疾病期间发现的水平。相比之下，未接种疫苗的个体在接种疫苗后表现出低气道抗体。在之前的COVID-19患者中，加强接种疫苗后气道抗体水平显著升高，突出了初免和加强接种疫苗对先前感染个体获得最佳粘膜保护的重要性。
Understanding the presence and durability of antibodies against SARS-CoV-2 in the airways is required to provide insights into the ability of individuals to neutralize the virus locally and prevent viral spread. Here, we longitudinally assessed both systemic and airway immune responses upon SARS-CoV-2 infection in a clinically well-characterized cohort of 147 infected individuals representing the full spectrum of COVID-19 severity, from asymptomatic infection to fatal disease. In addition, we evaluated how SARS-CoV-2 vaccination influenced the antibody responses in a subset of these individuals during convalescence as compared with naive individuals. Not only systemic but also airway antibody responses correlated with the degree of COVID-19 disease severity. However, although systemic IgG levels were durable for up to 8 months, airway IgG and IgA declined significantly within 3 months. After vaccination, there was an increase in both systemic and airway antibodies, in particular IgG, often exceeding the levels found during acute disease. In contrast, naive individuals showed low airway antibodies after vaccination. In the former COVID-19 patients, airway antibody levels were significantly elevated after the boost vaccination, highlighting the importance of prime and boost vaccinations for previously infected individuals to obtain optimal mucosal protection.
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影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
DOI：
10.1056/nejmra0910061
发表时间：
2010-12-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Fahy JV;Dickey BF
通讯作者：
Dickey BF
影响因子：
6.4
作者：
Guthmiller JJ;Stovicek O;Wang J;Changrob S;Li L;Halfmann P;Zheng NY;Utset H;Stamper CT;Dugan HL;Miller WD;Huang M;Dai YN;Nelson CA;Hall PD;Jansen M;Shanmugarajah K;Donington JS;Krammer F;Fremont DH;Joachimiak A;Kawaoka Y;Tesic V;Madariaga ML;Wilson PC
通讯作者：
Wilson PC
影响因子：
82.9
作者：
Brodin, Petter
通讯作者：
Brodin, Petter
影响因子：
2.7
作者：
Grissom, Colin K.;Brown, Samuel M.;Kuttler, Kathryn G.;Boltax, Jonathan P.;Jones, Jason;Jephson, Al R.;Orme, James F., Jr.
通讯作者：
Orme, James F., Jr.