Endocrine function in naturally long-living small mammals.
Endocrine function in naturally long-living small mammals.
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DOI：
10.1016/j.mce.2008.04.021
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发表时间：
2009-02-05
影响因子：
4.1
通讯作者：
Pinto M
中科院分区：
文献类型：
--
作者：
Buffenstein R;Pinto M
复杂的，高度整合的内分泌系统调节体细胞的维持和繁殖的各个方面，并已被广泛牵连作为一个重要的决定因素，寿命短的传统模式生物的老化研究。基因或实验操纵小鼠的激素谱已被证明可以决定性地改变寿命。这些生殖诱导的寿命延长机制可能不一定与人类和其他自然表现出成功的缓慢衰老的长寿生物有关。长寿的物种可能已经进化出了新的抗衰老防御机制，这与自然延缓衰老过程有密切关系。在这里，我们研究了现有的内分泌数据与维生素D，胰岛素，糖皮质激素和甲状腺内分泌系统的自然长寿的小哺乳动物。一般来说，长寿的啮齿动物和蝙蝠保持严格控制的这些关键多效性激素的基础水平较低，而不是寿命较短的啮齿动物。与遗传操纵的相似性表明，进化上保守的激素机制与寿命决定密切相关。
The complex, highly integrative endocrine system regulates all aspects of somatic maintenance and reproduction and has been widely implicated as an important determinant of longevity in short-lived traditional model organisms of aging research. Genetic or experimental manipulation of hormone profiles in mice has been proven to definitively alter longevity. These hormonally induced lifespan extension mechanisms may not necessarily be relevant to humans and other long-lived organisms that naturally show successful slow aging. Long-lived species may have evolved novel anti-aging defenses germane to naturally retarding the aging process. Here we examine the available endocrine data associated with the vitamin D, insulin, grlucocorticoid and thyroid endocrine systems of naturally long-living small mammals. Generally, long-living rodents and bats maintain tightly regulated lower basal levels of these key pleiotropic hormones than shorter-lived rodents. Similarities with genetically manipulated suggest that evolutionarily wellconserved hormonal mechanisms are integrally involved in lifespan determination.
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影响因子：
3.7
作者：
Caviedes-Vidal E;Karasov WH;Chediack JG;Fasulo V;Cruz-Neto AP;Otani L
通讯作者：
Otani L
影响因子：
4.8
作者：
Brown, CR;Brown, MB;Wingfield, JC
通讯作者：
Wingfield, JC
影响因子：
2.9
作者：
BAUMAN, WA
通讯作者：
BAUMAN, WA
影响因子：
5.8
作者：
BUFFENSTEIN, R;JARVIS, JUM;PETTIFOR, JM
通讯作者：
PETTIFOR, JM
影响因子：
1.4
作者：
Boonstra, R;Hubbs, AH;McColl, CJ
通讯作者：
McColl, CJ