Pathogenesis of brain edema and investigation into anti-edema drugs.
Pathogenesis of brain edema and investigation into anti-edema drugs.
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DOI：
10.3390/ijms16059949
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发表时间：
2015-04-30
影响因子：
5.6
通讯作者：
Koyama Y
中科院分区：
文献类型：
--
作者：
Michinaga S;Koyama Y
脑水肿是一种潜在的致命的病理状态，发生在脑损伤，如中风和头部创伤后。在水肿的脑中，细胞外液的过度积聚导致颅内压升高，从而导致神经功能受损。尽管脑水肿的严重性，目前只有对症治疗，以消除水肿液。因此，需要开发新的抗水肿药物。脑水肿的发病机制分为血管源性或细胞毒性水肿。血管源性水肿定义为血脑屏障（BBB）破坏和血清蛋白外渗导致的细胞外积液，而细胞毒性水肿的特征是细胞内积液导致的细胞肿胀。各种实验动物模型经常用于研究脑水肿的机制。许多可溶性因子和功能分子已被证实可诱导血脑屏障破坏或细胞肿胀，靶向这些因子的药物有望具有抗水肿作用。本文就脑水肿形成的机制、相关因素及抗水肿药物的可能性进行综述。
Brain edema is a potentially fatal pathological state that occurs after brain injuries such as stroke and head trauma. In the edematous brain, excess accumulation of extracellular fluid results in elevation of intracranial pressure, leading to impaired nerve function. Despite the seriousness of brain edema, only symptomatic treatments to remove edema fluid are currently available. Thus, the development of novel anti-edema drugs is required. The pathogenesis of brain edema is classified as vasogenic or cytotoxic edema. Vasogenic edema is defined as extracellular accumulation of fluid resulting from disruption of the blood-brain barrier (BBB) and extravasations of serum proteins, while cytotoxic edema is characterized by cell swelling caused by intracellular accumulation of fluid. Various experimental animal models are often used to investigate mechanisms underlying brain edema. Many soluble factors and functional molecules have been confirmed to induce BBB disruption or cell swelling and drugs targeted to these factors are expected to have anti-edema effects. In this review, we discuss the mechanisms and involvement of factors that induce brain edema formation, and the possibility of anti-edema drugs targeting them.
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影响因子：
10.8
作者：
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影响因子：
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DOI：
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发表时间：
2009-02-10
影响因子：
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