The genome sequence of the model ascomycete fungus Podospora anserina.
The genome sequence of the model ascomycete fungus Podospora anserina.
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DOI：
10.1186/gb-2008-9-5-r77
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发表时间：
2008
期刊：
影响因子：
12.3
通讯作者：
Silar P
中科院分区：
文献类型：
--
作者：
Espagne E;Lespinet O;Malagnac F;Da Silva C;Jaillon O;Porcel BM;Couloux A;Aury JM;Ségurens B;Poulain J;Anthouard V;Grossetete S;Khalili H;Coppin E;Déquard-Chablat M;Picard M;Contamine V;Arnaise S;Bourdais A;Berteaux-Lecellier V;Gautheret D;de Vries RP;Battaglia E;Coutinho PM;Danchin EG;Henrissat B;Khoury RE;Sainsard-Chanet A;Boivin A;Pinan-Lucarré B;Sellem CH;Debuchy R;Wincker P;Weissenbach J;Silar P
粗糙脉孢菌基因组的10倍覆盖度草图序列显示，自其与构巢曲霉分化以来，经历了高度动态的进化。
粪生子囊菌波氏足肿菌是一种用于研究真核生物和真菌生物学各个方面的模式生物，例如衰老、朊病毒和有性发育。
我们展示了波氏足肿菌基因组的10倍覆盖度草图序列，并与大量表达序列标签集合的序列相关联。与高等真核生物类似，波氏足肿菌的转录/剪接机制产生了大量非常规转录本。将波氏足肿菌基因组及其直系同源基因集与它的近亲构巢曲霉的基因组及其直系同源基因集进行比较，结果表明同线性保守性较差，进化的主要结果是同一染色体上的基因重排。波氏足肿菌基因组包含较少的重复序列，并且自其与构巢曲霉分离以来，通过基因重复进化出了新基因，尽管存在使重复序列发生突变的重复诱导点突变机制。我们还提供证据表明，在通向波氏足肿菌和构巢曲霉的谱系中发生了频繁的基因丢失。波氏足肿菌包含一组大量且高度特化的基因，这些基因参与利用其自然生境中常见的天然碳源。它包括可能参与木质素降解和高效纤维素分解的基因。
波氏足肿菌基因组的特征表明，自波氏足肿菌和构巢曲霉分化以来，经历了高度动态的进化，这使得前者具有利用与其自然生境需求相匹配的特定复杂碳源的能力。
A 10X draft sequence of Podospora anserina genome shows highly dynamic evolution since its divergence from Neurospora crassa. The dung-inhabiting ascomycete fungus Podospora anserina is a model used to study various aspects of eukaryotic and fungal biology, such as ageing, prions and sexual development. We present a 10X draft sequence of P. anserina genome, linked to the sequences of a large expressed sequence tag collection. Similar to higher eukaryotes, the P. anserina transcription/splicing machinery generates numerous non-conventional transcripts. Comparison of the P. anserina genome and orthologous gene set with the one of its close relatives, Neurospora crassa, shows that synteny is poorly conserved, the main result of evolution being gene shuffling in the same chromosome. The P. anserina genome contains fewer repeated sequences and has evolved new genes by duplication since its separation from N. crassa, despite the presence of the repeat induced point mutation mechanism that mutates duplicated sequences. We also provide evidence that frequent gene loss took place in the lineages leading to P. anserina and N. crassa. P. anserina contains a large and highly specialized set of genes involved in utilization of natural carbon sources commonly found in its natural biotope. It includes genes potentially involved in lignin degradation and efficient cellulose breakdown. The features of the P. anserina genome indicate a highly dynamic evolution since the divergence of P. anserina and N. crassa, leading to the ability of the former to use specific complex carbon sources that match its needs in its natural biotope.
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影响因子：
10.5
作者：
Bartee, L;Malagnac, F;Bender, J
通讯作者：
Bender, J
影响因子：
3.3
作者：
Bouhouche, K;Zickler, D;Arnaise, S
通讯作者：
Arnaise, S
影响因子：
3
作者：
Brown, DW;Cheung, F;Whitelaw, CA
通讯作者：
Whitelaw, CA
影响因子：
64.8
作者：
Cogoni, C;Macino, G
通讯作者：
Macino, G
影响因子：
--
作者：
Coppin, E;de Renty, C;Debuchy, R
通讯作者：
Debuchy, R