Early Assessment of Tumor Response to Radiation Therapy using High-Resolution Quantitative Microvascular Ultrasound Imaging.
Early Assessment of Tumor Response to Radiation Therapy using High-Resolution Quantitative Microvascular Ultrasound Imaging.
复制标题
DOI：
10.7150/thno.19703
复制
发表时间：
2018
期刊：
影响因子：
12.4
通讯作者：
Dayton PA
中科院分区：
文献类型：
--
作者：
Kasoji SK;Rivera JN;Gessner RC;Chang SX;Dayton PA
在放射治疗（RT）后数周至数月使用解剖成像测量肿瘤体积的变化是目前指示RT治疗反应的临床标准。对于肿瘤对治疗反应不成功的患者，这种方法是次优的，因为及时修改治疗方法可能会导致更好的临床结果。我们建议使用肿瘤微血管作为早期评估肿瘤对rt反应的生物标志物。声学血管造影是一种新型的超声造影技术，可以实现高分辨率微血管成像，并已被证明可以检测因癌症生长而导致的微血管结构变化。数据表明，声学血管造影可以检测到与RT反应相关的肿瘤微血管环境的纵向变化。方法：3组Fisher 344大鼠植入大鼠纤维肉瘤，分别给予15 Gy、20 Gy、25 Gy三个剂量水平的单次RT治疗，剂量率为300 MU/min。选择一个简单的治疗条件来测试我们的成像技术的可行性。所有肿瘤在治疗前后立即进行纵向成像，治疗后每3天进行一次纵向成像，共30天。声学血管造影（使用内部生产的微泡造影剂）和标准b型成像在每个成像时间点使用临床前Vevo770扫描仪和定制改进的双频换能器进行。结果：结果显示，各剂量组治疗后的肿瘤均在第3-15天开始对治疗产生反应，表现为肿瘤生长下降，血管密度下降。未经治疗的肿瘤体积和血管密度继续增加，直到它们达到直径2厘米的最大允许尺寸。完全控制（无复发）的肿瘤体积和血管密度继续减小，而在初始反应后进展的肿瘤体积和体积血管密度增加。复发肿瘤体积血管密度增加的时间比15、20、25 Gy剂量组分别早10.25±1.5天、6±0天和4±1.4天。还观察到肿瘤复发的剂量依赖性生长速率。结论：在这项可行性研究中，我们已经证明了声学血管造影检测血管密度纵向变化的能力，这被证明是肿瘤对RT反应的潜在生物标志物。
Measuring changes in tumor volume using anatomical imaging weeks to months post radiation therapy (RT) is currently the clinical standard for indicating treatment response to RT. For patients whose tumors do not respond successfully to treatment, this approach is suboptimal as timely modification of the treatment approach may lead to better clinical outcomes. We propose to use tumor microvasculature as a biomarker for early assessment of tumor response to RT. Acoustic angiography is a novel contrast ultrasound imaging technique that enables high-resolution microvascular imaging and has been shown to detect changes in microvascular structure due to cancer growth. Data suggest that acoustic angiography can detect longitudinal changes in the tumor microvascular environment that correlate with RT response. Methods: Three cohorts of Fisher 344 rats were implanted with rat fibrosarcoma tumors and were treated with a single fraction of RT at three dose levels (15 Gy, 20 Gy, and 25 Gy) at a dose rate of 300 MU/min. A simple treatment condition was chosen for testing the feasibility of our imaging technique. All tumors were longitudinally imaged immediately prior to and after treatment and then every 3 days after treatment for a total of 30 days. Both acoustic angiography (using in-house produced microbubble contrast agents) and standard b-mode imaging was performed at each imaging time point using a pre-clinical Vevo770 scanner and a custom modified dual-frequency transducer. Results: Results show that all treated tumors in each dose group initially responded to treatment between days 3-15 as indicated by decreased tumor growth accompanied with decreased vascular density. Untreated tumors continued to increase in both volume and vascular density until they reached the maximum allowable size of 2 cm in diameter. Tumors that displayed complete control (no tumor recurrence) continued to decrease in size and vascular density, while tumors that progressed after the initial response presented an increase in tumor volume and volumetric vascular density. The increase in tumor volumetric vascular density in recurring tumors can be detected 10.25 ± 1.5 days, 6 ± 0 days, and 4 ± 1.4 days earlier than the measurable increase in tumor volume in the 15, 20, and 25 Gy dose groups, respectively. A dose-dependent growth rate for tumor recurrence was also observed. Conclusions: In this feasibility study we have demonstrated the ability of acoustic angiography to detect longitudinal changes in vascular density, which was shown to be a potential biomarker for tumor response to RT.
登录
查看更多内容
影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
影响因子：
7.6
作者：
Gessner RC;Frederick CB;Foster FS;Dayton PA
通讯作者：
Dayton PA
DOI：
10.1016/j.ijrobp.2010.10.026
发表时间：
2012-01-01
影响因子：
7
作者：
Jabbari, Siavash;Weinberg, Vivian K.;Gottschalk, Alexander R.
通讯作者：
Gottschalk, Alexander R.
影响因子：
--
作者：
Cokkinos DD;Antypa EG;Skilakaki M;Kriketou D;Tavernaraki E;Piperopoulos PN
通讯作者：
Piperopoulos PN
影响因子：
4.2
作者：
Kim, Jinwook;Li, Sibo;Jiang, Xiaoning
通讯作者：
Jiang, Xiaoning