Expression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma.
Expression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma.
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THBS1、Cyr61、CTGF在食管鳞癌中的表达及预后意义
DOI：
10.1186/1471-2407-9-291
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发表时间：
2009-08-22
期刊：
影响因子：
3.8
通讯作者：
Li EM
中科院分区：
文献类型：
--
作者：
Zhou ZQ;Cao WH;Xie JJ;Lin J;Shen ZY;Zhang QY;Shen JH;Xu LY;Li EM
凝血酶敏感蛋白1（THBS 1）、富含半胱氨酸蛋白61（Cyr 61）和结缔组织生长因子（CTGF）均参与转化生长因子-β（TGF-β）信号通路，在肿瘤的发生发展中起重要作用。本研究旨在探讨这些蛋白在食管鳞状细胞癌（ESCC）中的表达及其与预后的关系。采用免疫组化和蛋白质印迹法检测THBS 1、Cyr 61和CTGF在食管鳞癌中的表达情况。THBS 1、Cyr 61和CTGF过表达与各种临床病理因素的相关性也通过卡方检验或Fisher精确概率检验来确定。通过Kaplan-Meier分析和对数秩检验评估生存分析。相对危险度采用多变量考克斯比例风险模型进行评估。THBS 1、Cyr 61和CTGF在食管鳞癌中均过表达。THBS 1过表达与TNM分期（P = 0.029）和区域淋巴结转移（P = 0.026）显著相关。Kaplan-Meier生存分析显示THBS 1、Cyr 61和CTGF的高表达与食管鳞癌患者的生存率相关（分别为P = 0.042、P = 0.020、P = 0.018）。多因素考克斯分析显示Cyr 61和CTGF是影响食管鳞癌预后的独立因素。Cyr 61、CTGF和THBS 1在食管鳞癌中均呈高表达，可能成为预测食管鳞癌患者预后的新的分子标志物。
Thrombospondin1 (THBS1), cystene-rich protein 61 (Cyr61) and connective tissue growth factor (CTGF) are all involved in the transforming growth factor-beta (TGF-β) signal pathway, which plays an important role in the tumorigenesis. The purpose of this study is to explore the expression and prognostic significance of these proteins in esophageal squamous cell carcinoma (ESCC). We used immunohistochemistry and western blotting to examine the expression status of THBS1, Cyr61 and CTGF in ESCC. Correlations of THBS1, Cyr61 and CTGF over-expressions with various clinicopathologic factors were also determined by using the Chi-square test or Fisher's exact probability test. Survival analysis was assessed by the Kaplan-Meier analysis and the log-rank test. Relative risk was evaluated by the multivariate Cox proportional hazards model. THBS1, Cyr61 and CTGF were all over-expressed in ESCC. THBS1 over-expression was significantly associated with TNM stage (P = 0.029) and regional lymph node involvement (P = 0.026). Kaplan-Meier survival analysis showed that over-expression of THBS1, Cyr61 or CTGF was related to poor survival of ESCC patients (P = 0.042, P = 0.020, P = 0.018, respectively). Multivariate Cox analysis demonstrated that Cyr61 and CTGF were independent factors in prognosis of ESCC. Cyr61, CTGF and THBS1 were all over-expressed in ESCC and might be new molecular markers to predict the prognosis of ESCC patients.
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影响因子：
4.5
作者：
Guerrero, David;Guarch, Rosa;Puras, Ana
通讯作者：
Puras, Ana
影响因子：
9.7
作者：
Miyamoto, Nobuki;Yamamoto, Hiroyuki;Shinomura, Yasuhisa
通讯作者：
Shinomura, Yasuhisa
DOI：
10.1093/jnci/89.3.219
发表时间：
1997-02-05
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Grossfeld, GD;Ginsberg, DA;Cote, RJ
通讯作者：
Cote, RJ
影响因子：
6.4
作者：
Rojas, Andres;Meherem, Shereen;Kim, Young-Ho;Washington, Mary Kay;Willis, Joseph E.;Markowitz, Sanford D.;Grady, William M.
通讯作者：
Grady, William M.
影响因子：
5.8
作者：
Planque N;Perbal B
通讯作者：
Perbal B