Social norm processing in adult social phobia: atypically increased ventromedial frontal cortex responsiveness to unintentional (embarrassing) transgressions.
Social norm processing in adult social phobia: atypically increased ventromedial frontal cortex responsiveness to unintentional (embarrassing) transgressions.
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DOI：
10.1176/appi.ajp.2010.09121797
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Pine DS
中科院分区：
文献类型：
--
作者：
Blair KS;Geraci M;Hollon N;Otero M;DeVido J;Majestic C;Jacobs M;Blair RJ;Pine DS
广泛性社交恐惧症(GSP)的定义是对社会反对的持续恐惧。然而，这种恐惧增加的神经基础及其中介因素尚不清楚。使用事件相关功能磁共振成像，我们检验了事件的意图是否对GSP的反应产生了不同的影响，事件的意图调节了健康个体对社会反对的神经反应。具体地说，GSP患者是否会对尴尬的、无意的违规行为表现出特别高的反应？16名GSP患者和16名年龄、智商和性别匹配的健康人在fMRI扫描中阅读故事，这些故事要么涉及中立的社会事件，要么涉及无意的社会违法行为(例如，在派对上被食物窒息并咳嗽)，或故意的社会违法行为(例如，在派对上不喜欢食物，并将其吐出)。在内侧前额叶皮质(MPFC)的腹侧区域观察到显著的逐组侵袭交互作用。相对于无意的违规行为，健康的人倾向于对故意的违规行为表现出更多的大胆反应。然而，GSP患者对无意违规的反应显著增加。此外，他们认为这些无意的违规行为明显比对照的人更令人尴尬。我们还观察到杏仁核和双侧脑岛的显著组主效应，反映了这些区域对所有事件类型的GSP反应升高。这些结果进一步表明，MPFC参与了GSP的病理生理学，特别是通过参与扭曲的自我参照加工。此外，目前的结果进一步强调了杏仁核和脑岛在GSP中更普遍地处理社会刺激的扩展作用。
Generalized social phobia (GSP) is defined by a persistent fear of social disapproval. However, the neural underpinnings of this increased fear and its mediating factors are unclear. Using event-related fMRI, we examined whether the intent of an event, which mediates the neural response to social disapproval in healthy individuals, differentially affects response in GSP. Specifically, would patients with GSP show particularly increased response to embarrassing, unintentional transgressions? Sixteen patients with GSP and sixteen age, IQ, and gender matched healthy individuals read stories during fMRI scans that either involved neutral social events, unintentional social transgressions (e.g., choking on food at party, and coughing it up), or intentional social transgressions (e.g., disliking food at party, and spitting it out). Significant group-by-transgression interactions were observed within ventral regions of medial prefrontal cortex (MPFC). Healthy individuals tended to show increased BOLD responses to intentional, relative to unintentional transgressions. The patients with GSP, however, showed significantly increased responses to the unintentional transgressions. In addition, they rated the unintentional transgressions as significantly more embarrassing than the comparison individuals. We also observed significant group main effects within the amygdala and bilateral insula, reflecting elevated GSP responses within these regions to all event types. These results further implicate the MPFC in the pathophysiology of GSP, specifically through its involvement in distorted self-referential processing. In addition, the current results further underscore the extended role of the amygdala and insula in the processing of social stimuli more generally in GSP.
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影响因子：
--
作者：
Guyer, Amanda E.;Lau, Jennifer Y. F.;McClure-Tone, Erin B.;Parrish, Jessica;Shiffrin, Nina D.;Reynolds, Richard C.;Chen, Gang;Blair, R. J. R.;Leibenluft, Ellen;Fox, Nathan A.;Ernst, Monique;Pine, Daniel S.;Nelson, Eric E.
通讯作者：
Nelson, Eric E.
影响因子：
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作者：
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通讯作者：
Hofmann, Stefan G.
影响因子：
6.6
作者：
Cox, BJ;Fleet, C;Stein, MB
通讯作者：
Stein, MB
影响因子：
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作者：
Beesdo, Katja;Bittner, Antje;Wittchen, Hans-Ulrich
通讯作者：
Wittchen, Hans-Ulrich
影响因子：
14.5
作者：
Berthoz, S.;Armony, J. L.;Dolan, R. J.
通讯作者：
Dolan, R. J.