Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety.
Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety.
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DOI：
10.1001/archpsyc.65.11.1303
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发表时间：
2008-11
影响因子：
--
通讯作者：
Nelson, Eric E.
中科院分区：
文献类型：
--
作者：
Guyer, Amanda E.;Lau, Jennifer Y. F.;McClure-Tone, Erin B.;Parrish, Jessica;Shiffrin, Nina D.;Reynolds, Richard C.;Chen, Gang;Blair, R. J. R.;Leibenluft, Ellen;Fox, Nathan A.;Ernst, Monique;Pine, Daniel S.;Nelson, Eric E.
当青少年焦虑症患者在威胁性情境中看到负价刺激时，他们的杏仁核和腹外侧前额叶皮质（vlPFC）功能障碍会表现出来。当预期的社会评价导致社交焦虑的青少年将同龄人误认为具有威胁性时，这种恐惧回路功能障碍也可能表现出来。为了确定是否负面评价微笑的同龄人在预期的社会评价照片参与杏仁核和vlPFC的差异，青少年与无社交焦虑。病例对照研究。政府临床研究所。14名青少年焦虑症与社会评价的显着关注和14名青少年没有精神病诊断相匹配的性别，年龄，智商和社会经济地位。事件相关功能磁共振成像测量血氧水平依赖信号。在神经影像学扫描之前和扫描过程中，参与者预期社会评价完成同行和自我评价。与事件相关的分析是根据参与者对特定同伴的评分进行的。参与者将40张同龄人的照片归类为他们愿意或不愿意参与社交互动的人。焦虑的青少年表现出更大的杏仁核激活比健康的青少年时，预期的评价，从同行以前评为不希望的互动。心理生理学的相互作用连接分析也显示了显着的正相关杏仁核和vlPFC激活在焦虑与健康的青少年在响应这些刺激。在焦虑和健康的青少年中，预期来自消极感知的同伴的社会评价会不同地调节杏仁核和vlPFC的参与。杏仁核和vlPFC功能障碍表现在青少年焦虑症的预期同侪评价的特定背景下。
Amygdala and ventrolateral prefrontal cortex (vlPFC) dysfunction manifests in adolescents with anxiety disorders when they view negatively valenced stimuli in threatening contexts. Such fear-circuitry dysfunction may also manifest when anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening. To determine whether photographs of negatively evaluated smiling peers viewed during anticipated social evaluation engage the amygdala and vlPFC differentially in adolescents with and without social anxiety. Case-control study. Government clinical research institute. Fourteen adolescents with anxiety disorders associated with marked concerns of social evaluation and 14 adolescents without a psychiatric diagnosis matched on sex, age, intelligence quotient, and socioeconomic status. Blood oxygenation level–dependent signal measured with event-related functional magnetic resonance imaging. Before and during neuroimaging scans, participants anticipating social evaluation completed peer- and self-appraisals. Event-related analyses were tailored to participants’ ratings of specific peers. Participants classified 40 pictures of same-age peers as ones with whom they did or did not want to engage in a social interaction. Anxious adolescents showed greater amygdala activation than healthy adolescents when anticipating evaluation from peers previously rated as undesired for an interaction. Psychophysiological interaction connectivity analyses also revealed a significant positive association between amygdala and vlPFC activation in anxious vs healthy adolescents in response to these stimuli. Anticipating social evaluation from negatively perceived peers modulates amygdala and vlPFC engagement differentially in anxious and healthy adolescents. Amygdala and vlPFC dysfunction manifests in adolescent anxiety disorders in specific contexts of anticipated peer evaluation.
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影响因子：
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