The contribution of maternal serum markers in the early prenatal diagnosis of molar pregnancies.
The contribution of maternal serum markers in the early prenatal diagnosis of molar pregnancies.
复制标题
母体血清标志物在葡萄胎妊娠早期产前诊断中的贡献。
作者：
E. Jauniaux;N. Bersinger;B. Gulbis;S. Meuris
本研究的目的是评估孕妇血清标志物在早期产前诊断磨牙妊娠的有用性。回顾性分析10例妊娠11-13周的葡萄胎患者的超声表现、细胞遗传学和组织病理学改变，并与孕妇血清人绒毛膜促性腺激素（HCG）、甲胎蛋白（AFP）、妊娠相关血浆蛋白A（PAPP-A）和妊娠特异性β 1-糖蛋白（SP1）进行比较。在所有病例中，游离β-HCG和完整HCG浓度都非常高[>或=中位数（MoM）的2.5倍]。AFP浓度在所有单胎完全性葡萄胎病例中均极低（≤ 0.5 MoM），在1例双胎完全性葡萄胎、1例三倍体部分性葡萄胎和2例整倍体部分性葡萄胎病例中较高（≥ 2.5 MoM）。血清PAPP-A和SP1在完全性葡萄胎中升高。结合超声特征、母体血清蛋白和胎儿细胞遗传学检查结果，可以对解剖学正常胎儿的葡萄胎妊娠进行早期宫内鉴别诊断和围产期管理。
The aim of this study was to evaluate the usefulness of maternal serum markers in the early prenatal diagnosis of molar pregnancies. The ultrasound features, cytogenetic and histopathological findings of 10 cases of molar pregnancy diagnosed at 11-13 weeks of gestation were compared retrospectively with the maternal serum concentrations of human chorionic gonadotrophin (HCG), alpha fetoprotein (AFP), pregnancy-associated plasma protein A (PAPP-A) and pregnancy-specific beta1-glycoprotein (SP1). Free beta-HCG and intact HCG concentrations were very high [> or = 2.5 multiples of the median (MoM)] in all cases. AFP concentrations were extremely low in all cases of singleton complete moles (< or = 0.5 MoM) and were high in one case of twin complete mole, in one case of triploid partial mole and two cases of euploid partial mole (> or = 2.5 MoM). Serum PAPP-A and SP1 were high in complete moles. The combined use of ultrasound features, maternal serum proteins and fetal cytogenetic findings should enable the early differential diagnosis in utero and perinatal management of those molar pregnancies presenting with an anatomically normal fetus.
衣原体调节 HeLa 细胞中的 γ 干扰素、白细胞介素 1 β 和肿瘤坏死因子 α 受体的表达。
影响因子：
3.1
作者：
Shirey,KariAnn;Carlin,JosephM
通讯作者：
Carlin,JosephM