Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma.
Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma.
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DOI：
10.1182/bloodadvances.2022007127
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发表时间：
2022-09-13
期刊：
影响因子：
7.5
通讯作者：
El-Jawahri, Areej
中科院分区：
文献类型：
--
作者：
O'Donnell, Elizabeth K.;Shapiro, Yael N.;Yee, Andrew J.;Nadeem, Omar;Laubach, Jacob P.;Branagan, Andrew R.;Anderson, Kenneth C.;Mo, Clifton C.;Munshi, Nikhil C.;Ghobrial, Irene M.;Sperling, Adam S.;Agyemang, Emerentia A.;Burke, Jill N.;Harrington, Cynthia C.;Hu, Bonnie Y.;Richardson, Paul G.;Raje, Noopur S.;El-Jawahri, Areej
治疗MM患者的护理人员在整个疾病连续体中经历了大量的心理困扰，特别是焦虑。大多数护理人员报告说，肿瘤学家告诉他们，病人的MM是无法治愈的，但很大一部分人认为病人是可以治愈的。虽然多发性骨髓瘤（MM）患者的照顾者在整个病程中支持其亲人方面发挥着关键作用，但缺乏研究照顾者生活质量（QOL），心理困扰和预后意识。我们对接受MM治疗的患者及其护理人员进行了一项横断面、多中心研究。根据治疗线，将合格的护理人员入组3个队列之一。照顾者完成有效的问卷调查，以评估他们的生活质量，心理困扰，和预后的看法。我们入组了127名MM患者的护理人员（新诊断[n = 43]，2-3线治疗[n = 40]和≥4线治疗[n = 44]）。护理人员的生活质量和心理困扰没有不同的治疗线。有临床意义的焦虑、抑郁和创伤后应激障碍症状的发生率分别为44.1%（56/127）、15.8%（20/127）和24.4%（31/127）。当在二人组中进行检查时，照顾者报告临床显著焦虑的比率较高（44.4% [55/124] vs 22.5% [28/124]）。（84.2%，101/120）报告肿瘤科医生曾告知他们患者的癌症无法治愈;然而，只有50.9%（58/114）和53.6%（59/110）的照顾者分别承认病人的癌症是晚期和不可治愈的。接受MM治疗的患者的护理人员在整个疾病连续体中经历了大量的心理困扰，特别是焦虑。大多数MM患者的护理人员报告说，了解患者的预后非常重要，并报告说肿瘤学家告诉他们患者无法治愈。然而，相当一部分护理人员认为患者的MM是可治愈的。
Caregivers of patients treated for MM experience substantial psychological distress across the disease continuum, particularly anxiety. The majority of caregivers report the oncologist told them the patient’s MM was incurable, yet a large portion believe the patient curable. Although caregivers of patients with multiple myeloma (MM) play a critical role in supporting their loved ones throughout the illness course, studies examining caregiver quality of life (QOL), psychological distress, and prognostic awareness are lacking. We conducted a cross-sectional, multisite study of patients undergoing treatment with MM and their caregivers. Eligible caregivers were enrolled to 1 of 3 cohorts based on lines of therapy. Caregivers completed validated questionnaires to assess their QOL, psychological distress, and perceptions of prognosis. We enrolled 127 caregivers of patients with MM (newly diagnosed [n = 43], 2-3 lines of therapy [n = 40], and ≥4 lines of therapy [n = 44]). Caregiver QOL and psychological distress did not differ by line of therapy. The rate of clinically significant anxiety, depression, and posttraumatic stress disorder symptoms were 44.1% (56/127), 15.8% (20/127), and 24.4% (31/127), respectively. When examined in dyads, caregivers reported higher rates of clinically significant anxiety (44.4% [55/124] vs 22.5% [28/124]) compared with patients with MM. Most caregivers (84.2%, 101/120) reported that the oncologist had informed them that the patient’s cancer was incurable; however, only 50.9% (58/114) and 53.6% (59/110) of caregivers acknowledged the patient’s cancer was terminal and incurable, respectively. Caregivers of patients undergoing treatment for MM experience substantial psychological distress across the disease continuum, particularly anxiety. The majority of caregivers of patients with MM report that knowing the patient’s prognosis is extremely important and report that the oncologist told them that the patient was incurable. Nevertheless, a significant portion of caregivers believe that the patient’s MM is curable.
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影响因子：
6.2
作者：
Badr, Hoda;Smith, Cardinale B.;Goldstein, Nathan E.;Gomez, Jorge E.;Redd, William H.
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