Load transfer, damage, and failure in ligaments and tendons.
Load transfer, damage, and failure in ligaments and tendons.
复制标题
DOI：
10.1002/jor.24134
复制
发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Weiss JA
中科院分区：
文献类型：
--
作者：
Zitnay JL;Weiss JA
韧带和肌腱的功能是支撑和传递施加到肌肉骨骼系统的负荷。这些组织通常能够发挥其功能数十年;然而，结缔组织疾病和损伤可能会损害韧带和肌腱的完整性。一系列蛋白质和非蛋白质成分以从胶原分子到组织的复杂结构层级组合，覆盖纳米到厘米的长度尺度，控制组织功能并赋予特征性的非线性材料行为。本文综述了韧带和肌腱的结构，其组成部分的作用，跨层次结构的负荷转移，以及目前的理解如何发生在这些组织中的损害。疾病和损伤可以改变韧带和肌腱的组成和结构组织，影响组织功能，同时也提供了对单个成分的作用和相互作用的见解。这里介绍的研究和技术有助于理解组织成分和物理机制（例如拉伸，滑动）之间的关系，这些机制控制着长度尺度上和长度尺度之间的材料行为。近年来，新技术已经发展到探测更小的长度尺度，并可能有助于阐明负荷转移和损伤的机制，以及参与韧带和肌腱损伤的最早阶段的分子成分。从分子到组织水平的负荷转移和损伤的详细了解可以阐明结缔组织疾病的治疗目标，并为预防和恢复韧带和肌腱损伤的实践提供信息。
The function of ligaments and tendons is to support and transmit loads applied to the musculoskeletal system. These tissues are often able to perform their function for many decades; however, connective tissue disease and injury can compromise ligament and tendon integrity. A range of protein and non-protein constituents, combined in a complex structural hierarchy from the collagen molecule to the tissue and covering nanometer to centimeter length scales, govern tissue function and impart characteristic non-linear material behavior. This review summarizes the structure of ligaments and tendons, the roles of their constituent components for load transfer across the hierarchy of structure, and the current understanding of how damage occurs in these tissues. Disease and injury can alter the constituent make-up and structural organization of ligaments and tendons, affecting tissue function, while also providing insight to the role and interactions of individual constituents. The studies and techniques presented here have helped to understand the relationship between tissue constituents and the physical mechanisms (e.g. stretching, sliding) that govern material behavior at and between length scales. In recent years, new techniques have been developed to probe ever smaller length scales and may help to elucidate mechanisms of load transfer and damage and the molecular constituents involved in the in the earliest stages of ligament and tendon damage. A detailed understanding of load transfer and damage from the molecular to the tissue level may elucidate targets for the treatment of connective tissue diseases and inform practice to prevent and rehabilitate ligament and tendon injuries.
登录
查看更多内容
DOI：
10.1002/jor.20722
发表时间：
2009-02
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Fung DT;Wang VM;Laudier DM;Shine JH;Basta-Pljakic J;Jepsen KJ;Schaffler MB;Flatow EL
通讯作者：
Flatow EL
影响因子：
2.8
作者：
Attia, Mohamed;Scott, Alexander;Martelly, Isabelle
通讯作者：
Martelly, Isabelle
影响因子：
2.7
作者：
Buehler, Markus J.
通讯作者：
Buehler, Markus J.
影响因子：
4.5
作者：
Cheng, Vinton W. T.;Screen, Hazel R. C.
通讯作者：
Screen, Hazel R. C.
影响因子：
3.8
作者：
Elliott, DM;Robinson, PS;Soslowsky, LJ
通讯作者：
Soslowsky, LJ