Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers.
Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers.
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DOI：
10.1371/journal.pone.0079680
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Romana M
中科院分区：
文献类型：
--
作者：
Connes P;Lamarre Y;Hardy-Dessources MD;Lemonne N;Waltz X;Mougenel D;Mukisi-Mukaza M;Lalanne-Mistrih ML;Tarer V;Tressières B;Etienne-Julan M;Romana M
腿溃疡是镰状细胞性贫血（SCA）患者的致残并发症，但确切的病理生理机制尚不清楚。本研究的目的是确定血液学和血液流变学改变与复发性腿部溃疡相关。研究人员招募了62名从未经历过腿部溃疡（ULC-）的SCA患者和13名有复发性腿部溃疡（ULC+）阳性病史（但在研究时没有腿部溃疡）的SCA患者。所有患者均处于稳定状态。采集血液进行血液学、生化（溶血标志物）和血液流变学分析（血液粘度、红细胞变形性和聚集性）。计算每位受试者的红细胞氧运输效率的血细胞黏度比（HVR）。ULC+组患者比ULC-组患者年龄大。贫血（红细胞计数、红细胞压积和血红蛋白水平）在ULC+组更为明显。乳酸脱氢酶水平ULC+组高于ULC-组。两组之间的血液粘度和红细胞聚集特性均无差异。ULC+组HVR较低，RBC变形能力有降低趋势。我们的研究证实，SCA患者腿部溃疡复发时溶血率和贫血增加。此外，我们的数据表明，虽然全身血液粘度不是该并发症病理生理的主要因素，但红细胞氧运输效率降低（即红细胞压积/粘度比低）可能起作用。
Leg ulcer is a disabling complication in patients with sickle cell anemia (SCA) but the exact pathophysiological mechanisms are unknown. The aim of this study was to identify the hematological and hemorheological alterations associated with recurrent leg ulcers. Sixty-two SCA patients who never experienced leg ulcers (ULC-) and 13 SCA patients with a positive history of recurrent leg ulcers (ULC+) - but with no leg ulcers at the time of the study – were recruited. All patients were in steady state condition. Blood was sampled to perform hematological, biochemical (hemolytic markers) and hemorheological analyses (blood viscosity, red blood cell deformability and aggregation properties). The hematocrit-to-viscosity ratio (HVR), which reflects the red blood cell oxygen transport efficiency, was calculated for each subject. Patients from the ULC+ group were older than patients from the ULC- group. Anemia (red blood cell count, hematocrit and hemoglobin levels) was more pronounced in the ULC+ group. Lactate dehydrogenase level was higher in the ULC+ group than in the ULC- group. Neither blood viscosity, nor RBC aggregation properties differed between the two groups. HVR was lower and RBC deformability tended to be reduced in the ULC+ group. Our study confirmed increased hemolytic rate and anemia in SCA patients with leg ulcers recurrence. Furthermore, our data suggest that although systemic blood viscosity is not a major factor involved in the pathophysiology of this complication, decreased red blood cell oxygen transport efficiency (i.e., low hematocrit/viscosity ratio) may play a role.
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影响因子：
1.5
作者：
Giraldi, S;Abbage, KT;Neto, JF
通讯作者：
Neto, JF
影响因子：
2.9
作者：
Detterich J;Alexy T;Rabai M;Wenby R;Dongelyan A;Coates T;Wood J;Meiselman H
通讯作者：
Meiselman H
影响因子：
20.3
作者：
Bartolucci, Pablo;Brugnara, Carlo;Galacteros, Frederic
通讯作者：
Galacteros, Frederic
影响因子：
3.7
作者：
Bowers, Andre S.;Reid, Harvey L.;Reid, Marvin
通讯作者：
Reid, Marvin
影响因子：
3.7
作者：
Taylor, James G. V., I;Nolan, Vikki G.;Steinberg, Martin H.
通讯作者：
Steinberg, Martin H.