Advances in Designing and Developing Vaccines, Drugs and Therapeutic Approaches to Counter Human Papilloma Virus.
Advances in Designing and Developing Vaccines, Drugs and Therapeutic Approaches to Counter Human Papilloma Virus.
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DOI：
10.3389/fimmu.2018.02478
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发表时间：
2018
影响因子：
7.3
通讯作者：
Chaicumpa W
中科院分区：
文献类型：
--
作者：
Dadar M;Chakraborty S;Dhama K;Prasad M;Khandia R;Hassan S;Munjal A;Tiwari R;Karthik K;Kumar D;Iqbal HMN;Chaicumpa W
人乳头瘤病毒（HPV）是一种以皮肤间传播方式传播的病毒感染。 HPV 每年导致超过 500,000 例癌症病例，包括宫颈癌、肛门生殖器癌和口咽癌等。 HPV 疫苗接种已成为世界范围内的公共卫生问题，通过与国际联盟启动国家计划来预防 HPV 感染病例，包括癌前病变、宫颈癌和生殖器疣，特别是在青少年女性和男性人群中。目前，在发展中国家用于疫苗接种计划的现有预防性和治疗性疫苗价格昂贵。免疫疗法、生物技术、重组DNA技术和分子生物学以及替代和补充医学系统的最新进展为设计和开发有效的预防和治疗疫苗、药物和治疗方法以有效对抗HPV铺平了新的途径和宝贵的机会。对此类进展的探索和更多研究可能会导致全世界 HPV 病例的发病率逐渐降低。本综述介绍了针对 HPV 的先进预防和治疗方法的当前全球情况和未来前景，以及有效对抗 HPV 感染及其癌症病症的药物、疫苗和治疗方案的进展和进展的最新专利报道。
Human papillomavirus (HPV) is a viral infection with skin-to-skin based transmission mode. HPV annually caused over 500,000 cancer cases including cervical, anogenital and oropharyngeal cancer among others. HPV vaccination has become a public-health concern, worldwide, to prevent the cases of HPV infections including precancerous lesions, cervical cancers, and genital warts especially in adolescent female and male population by launching national programs with international alliances. Currently, available prophylactic and therapeutic vaccines are expensive to be used in developing countries for vaccination programs. The recent progress in immunotherapy, biotechnology, recombinant DNA technology and molecular biology along with alternative and complementary medicinal systems have paved novel ways and valuable opportunities to design and develop effective prophylactic and therapeutic vaccines, drugs and treatment approach to counter HPV effectively. Exploration and more researches on such advances could result in the gradual reduction in the incidences of HPV cases across the world. The present review presents a current global scenario and futuristic prospects of the advanced prophylactic and therapeutic approaches against HPV along with recent patents coverage of the progress and advances in drugs, vaccines and therapeutic regimens to effectively combat HPV infections and its cancerous conditions.
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影响因子：
3.7
作者：
Amine A;Rivera S;Opolon P;Dekkal M;Biard DS;Bouamar H;Louache F;McKay MJ;Bourhis J;Deutsch E;Vozenin-Brotons MC
通讯作者：
Vozenin-Brotons MC
DOI：
10.1086/598981
发表时间：
2009-06-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Castle PE;Kreimer AR;Wacholder S;Wheeler CM;Koutsky LA;Rydzak G;Buckman DW;Graubard B;Schiffman M
通讯作者：
Schiffman M
影响因子：
1.2
作者：
Archambault J;Melendy T
通讯作者：
Melendy T
影响因子：
6.8
作者：
Albarran y Carvajal, Antonio;de la Garza, Alfonso;Rosales, Ricardo
通讯作者：
Rosales, Ricardo
影响因子：
3.6
作者：
AMER, M;TOSSON, Z;ALGENDY, AA
通讯作者：
ALGENDY, AA